B3056

Bisindolylmaleimide II

≥97% (Mixture of 2 isomers)

• Empirical Formula (Hill Notation): C₂₇H₂₆N₄O₂
• CAS Number: 137592-45-1
• Molecular Weight: 438.52
• MDL number: MFCD00236430
• UNSPSC Code: 12352111
• PubChem Substance ID: 329773212
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• Assay: ≥97% (Mixture of 2 isomers)
• form: powder
• solubility: DMSO: soluble; ethanol: soluble
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CN1CCCC1CCn2cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c6ccccc26
• InChI: 1S/C27H26N4O2/c1-30-13-6-7-17(30)12-14-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-15-28-22-10-4-2-8-18(20)22/h2-5,8-11,15-17,28H,6-7,12-14H2,1H3,(H,29,32,33)
• InChI key: LBFDERUQORUFIN-UHFFFAOYSA-N

Description

Application

Bisindolylmaleimide II (BIS II) has been used:

• as a protein kinase C (PKC) inhibitor to study its effects on cardiomyocyte phenotypes
• as a PKC inhibitor along with methanandamide (mAEA) to study its effects on murine gastric vagal afferent (GVA) mechanosensitivity
• as a PKC/protein kinase A (PKA) inhibitor to study its effects on bone-marrow cells

Biochem/physiol Actions

Bisindolylmaleimide II (BIS II) acts as a dual protein kinase A/C (PKA/C) inhibitor.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves