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About This Item
Empirical Formula (Hill Notation):
C12H12ClNO2S
CAS Number:
Molecular Weight:
269.75
Beilstein:
2217205
EC Number:
MDL number:
UNSPSC Code:
12352101
PubChem Substance ID:
NACRES:
NA.26
product line
BioReagent
Quality Level
Assay
≥99% (HPLC)
form
powder and chunks
color
yellow to yellow-orange
mp
72-74 °C (lit.)
solubility
acetone: 20 mg/mL
suitability
suitable for amino acid labeling
storage temp.
2-8°C
SMILES string
CN(C)c1cccc2c(cccc12)S(Cl)(=O)=O
InChI
1S/C12H12ClNO2S/c1-14(2)11-7-3-6-10-9(11)5-4-8-12(10)17(13,15)16/h3-8H,1-2H3
InChI key
XPDXVDYUQZHFPV-UHFFFAOYSA-N
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Application
A fluorogenic reagent for fluorescent N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC.
Dansyl chloride has been used:
- as a fluorogenic reagent for fluorescent N-terminal derivatization of amino acids and peptides and detection by reverse phase high performance liquid chromatography (HPLC)
- in the derivatization of plasma samples
- in the quantification of immobilized alkaline phosphatase
Biochem/physiol Actions
Dansyl chloride is a sulfonyl chloride compound. It is used to end tag amino groups of peptides and proteins. Dansyl chloride is used for derivatization of free amino acids and amines in neural samples and biological fluids. It is used to study fluorescent conjugates of albumin, protein conformational changes studies and active site characterization.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B
Storage Class Code
8A - Combustible corrosive hazardous materials
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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