E1530

Anti-phospho-Epidermal Growth Factor Receptor (pTyr¹⁰⁸⁶) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

• Synonym(s): Anti-phospho-EGFR (pTyr¹⁰⁸⁶)
• MDL number: MFCD03845326
• UNSPSC Code: 51111800
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous glycerol solution
• mol wt: antigen ~185 kDa
• species reactivity: human, mouse, rat
• technique(s): western blot: 1:1,000
• UniProt accession no.: P00533
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr1086)
• Gene Information: human ... EGFR(1956) ; mouse ... Egfr(13649)

Description

Immunogen

synthetic phosphopeptide derived from the region of EGFR that contains tyrosine 1086.

Biochem/physiol Actions

EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer. Tyr1086 is a minor autophosphorylation site and enables the internalization of the receptor.

Physical form

Solution in Dulbecco′s phosphate buffered saline without Mg²⁺ and Ca²⁺, pH 7.3 with 50% glycerol, 1 mg/mL BSA (protease and IgG free) and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids