H8876
5-Hydroxyindole-3-acetic acid
≥98% (HPLC), crystalline
Synonym(s):
5-HIAA
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About This Item
Empirical Formula (Hill Notation):
C10H9NO3
CAS Number:
Molecular Weight:
191.18
Beilstein:
168797
EC Number:
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
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Product Name
5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline
Quality Level
Assay
≥98% (HPLC)
form
crystalline
color
white to purple
mp
161-164 °C (dec.) (lit.)
storage temp.
−20°C
SMILES string
OC(=O)Cc1c[nH]c2ccc(O)cc12
InChI
1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14)
InChI key
DUUGKQCEGZLZNO-UHFFFAOYSA-N
Gene Information
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General description
5-Hydroxyindole-3-acetic acid (5-HIAA) is the catabolic end product of serotonin pathway. 5-HIAA is present in body fluids like cerebrospinal fluid (CSF), blood and urine. The expression levels of 5-HIAA is different among the normal and cancer patients. Sepiapterin reductase deficiency results in low level of 5-HIAA in CSF. 5-HIAA level is low in CSF in patients with bipolar 1 disorder with childhood attention-deficit hyperactivity disorder (ADHD).
Application
5-Hydroxyindole-3-acetic acid has been used as standard for the measurement of 5-HIAA in the brain tissue of mice using high performance liquid chromatography (HPLC).
Biochem/physiol Actions
Major serotonin metabolite.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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