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M1275

Sigma-Aldrich

Naproxen sodium

98.0-102.0%

Synonym(s):

(S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):
C14H13NaO3
CAS Number:
26159-34-2
Molecular Weight:
252.24
EC Number:
247-486-2
MDL number:
MFCD00058507
UNSPSC Code:
12352200
PubChem Substance ID:
57654352
NACRES:
NA.77
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biological source

synthetic (organic)

Quality Level

200

Assay

98.0-102.0%

form

powder

solubility

water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow

originator

Bayer

SMILES string

[Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O

InChI

1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1

InChI key

CDBRNDSHEYLDJV-FVGYRXGTSA-M

Gene Information

human ... PTGS1(5742), PTGS2(5743)

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Show Differences

1 of 4

This Item
I14150426393Y0002263
Diisobutylamine 99%

135186

Diisobutylamine

Isobutylamine 99%

I14150

Isobutylamine

1-tert-Butyl-3-ethylcarbodiimide 99%

426393

1-tert-Butyl-3-ethylcarbodiimide

vibrant-m

Y0002263

N-Nitroso-diisopropylamine

assay

99%

assay

99%

assay

99%

assay

-

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

-

bp

137-139 °C (lit.)

bp

64-71 °C (lit.)

bp

137-139 °C (lit.)

bp

-

refractive index

n20/D 1.4081 (lit.)

refractive index

n20/D 1.397 (lit.)

refractive index

n20/D 1.432 (lit.)

refractive index

-

form

liquid

form

liquid

form

liquid

form

-

mp

−77 °C (lit.)

mp

−85 °C (lit.)

mp

-

mp

-

General description

Naproxen belongs to phenylacetic acid class of Non-steroidal anti-inflammatory drugs (NSAIDs).[1]

Application

Naproxen sodium has been used to evaluate the thermodynamics of biomolecular interaction with bovine and human serum albumin.[1] It has also been used to evaluate its efficiency in reducing the response of spinal dorsal horn neurons to noxious knee joint rotation.[2]

Biochem/physiol Actions

Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.
Naproxen binds preferably to serum albumin. The S-enantiomer of naproxen is 28-fold more potential as an anti-inflammatory drug compared to the R-isomer. The R-isomer is found to be a liver toxin and causes gastrointestinal disorders.[1]

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H302,H360

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1A

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
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    Certificates of Analysis (COA)

    Lot/Batch Number
    MKCP3544
    MKCL8987
    MKCK1762
    MKCJ5550
    MKCG5354

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    Influence of achiral amine additives on the Orito's reaction.
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    J. Mol. Catal. A: Chem., 357, 87-94 (2012)
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    Ivanov AV, et al.
    Russian Journal of Coordination Chemistry, 33(4), 233-243 (2007)
    Sarah Otto et al.
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    Polysaccharides have been used widely in many industries, from food technology and mining to cosmetics and biomedical applications. Over recent years there has been growing interest in the development of responsive polysaccharides with unique and switchable properties, particularly systems that

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