Skip to Content
MilliporeSigma

Skip To

N1915

Sigma-Aldrich

Nebivolol hydrochloride

≥98% (HPLC)

Synonym(s):

Narbivolol, Nebilet, R-65824, rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride

Sign Into View Organizational & Contract Pricing

Select a Size

1 EA
₹117,308.06

₹117,308.06


Please contact Customer Service for Availability

Request a Bulk Order

Select a Size

Change View
1 EA
₹117,308.06

About This Item

Empirical Formula (Hill Notation):
C22H25F2NO4 · HCl
CAS Number:
Molecular Weight:
441.90
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

₹117,308.06


Please contact Customer Service for Availability

Request a Bulk Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: ≥20 mg/mL

originator

Forest Labs

storage temp.

room temp

SMILES string

Cl.O[C@@H](CNC[C@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@H]3CCc4cc(F)ccc4O3

InChI

1S/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H/t17-,18-,21-,22+;/m0./s1

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
A2846Y000229954764
Neoxanthin ≥90% (HPLC)

54764

Neoxanthin

form

powder

form

solid

form

-

form

solid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

≥90% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

room temp

storage temp.

-

storage temp.

2-8°C

storage temp.

−20°C

storage condition

desiccated

storage condition

desiccated

storage condition

-

storage condition

-

solubility

DMSO: ≥20 mg/mL

solubility

H2O: soluble

solubility

-

solubility

-

Application

Nebivolol hydrochloride has been used as a standard in the validation of high-performance thin-layer chromatography (HPTLC)-densitometry method.[1] It may be used in calibration curve preparation and absorption spectrum studies using spectrophotometry.[2]

Biochem/physiol Actions

Nebivolol hydrochloride (NEB) is used as a racemic mixture for clinical studies.[3] It stabilizes membrane and possesses intrinsic sympathomimetic functionality.[3] Nebivolol interaction with π-acceptors (2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), 2,4-dinitrophenol (DNP) and 2,4,6-trinitrophenol (picric acid; PA)) is useful in the spectrophotometric detection methods.[2]
Nebivolol is a competitive, highly selective b1-receptor antagonist with mild vasodialating properties, possibly due to an interaction with the L-arginine/ NO pathway, and is used for treatment of essential hypertension.
Nebivolol is a competitive, highly selective b1-receptor antagonist with mild vasodialating properties, possibly due to an interaction with the L-arginine/ NO pathway, and is used for treatment of essential hypertension. It is 40-fold selective for β1 vs. β2, and lacks ISA (intrinsic sympathomimetic activity).

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

P Kielczynski et al.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 46(1), 233-238 (2008-02-02)
In this paper the theoretical analysis and the results of testing of a piezoelectric cantilever for the investigation of material surfaces are presented. The cantilever consists of a thin piezoelectric plate bonded with a thin metal (e.g., molybdenum) foil. The
Charles F Baker et al.
Dalton transactions (Cambridge, England : 2003), (9)(9), 1298-1303 (2004-07-15)
New molybdenum(VI) nitride oxides were synthesised by the reaction of strontium nitride and calcium nitride with molybdenum foil at high temperature in sealed stainless steel crucibles. The reactions yielded single crystalline products determined by X-ray diffraction to form complex structures
J G Watkins et al.
The Review of scientific instruments, 79(10), 10F125-10F125 (2008-12-03)
Two modular arrays of Langmuir probes designed to handle a heat flux of up to 25 MW/m(2) for 10 s exposures have been installed in the lower divertor target plates of the DIII-D tokamak. The 20 pyrolytic graphite probe tips
Michael N Evans
Rapid communications in mass spectrometry : RCM, 22(14), 2211-2219 (2008-06-11)
A reactor for converting cellulose into carbon monoxide for subsequent oxygen isotopic analysis via continuous flow isotope ratio mass spectrometry is described. The system employs an induction heater to produce temperatures >or=1500 degrees C within a molybdenum foil crucible positioned
Dattatray J Late et al.
Nanotechnology, 19(26), 265605-265605 (2008-07-02)
Nanocrystalline lanthanum hexaboride (LaB(6)) films have been deposited on molybdenum foil by the pulsed laser deposition (PLD) technique. The as-deposited films were characterized by x-ray diffraction (XRD), scanning electron microscopy (SEM) and atomic force microscopy (AFM). The XRD pattern shows

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service