N6252

Norharmane

≥98% (TLC), crystalline, monoamine oxidase inhibitor

• Synonym(s): β-Carboline, 9H-Pyrido[3,4-b]indole
• Empirical Formula (Hill Notation): C₁₁H₈N₂
• CAS Number: 244-63-3
• Molecular Weight: 168.19
• EC Number: 205-959-0
• MDL number: MFCD00004956
• UNSPSC Code: 12352200
• PubChem Substance ID: 24897776
• NACRES: NA.77

Properties

• Product Name: Norharmane, crystalline
• form: crystalline
• Quality Level: 200
• color: light yellow
• storage temp.: 2-8°C
• SMILES string: c1ccc2c(c1)[nH]c3cnccc23
• InChI: 1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H
• InChI key: AIFRHYZBTHREPW-UHFFFAOYSA-N
• Gene Information: human ... IKBKB(3551) ; rat ... Gabra2(29706)

Description

General description

Norharmane is an alkaloid widely present in living organisms and can also be chemically synthesized. It is a β-carboline derivative composed of indole and pyridine.

Application

Norharmane has been used:

• as a β-carboline to study its effect on nigrostriatal dopamine (DA) neurons
• as an internal standard in gas chromatography-mass spectrometry (GC-MS) analyses using Conidiobulus coronatus filtrates
• as a β-carboline-3-carboxylic acid N-methylamide (CMA) analog to study its binding ability with Mcm2-7 (minichromosome maintenance)

Biochem/physiol Actions

Inhibitor of indoleamine 2,3-dioxygenase (IDO).

Norharmane and its derivative exhibit anti-cancer properties. It acts as a monoamine oxidase (MAO) inhibitor and might benefit Parkinson′s disease (PD). High levels of β-carboline in plasma are found in PD.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves