R8657

Razoxane

>98% (HPLC)

• Synonym(s): (±)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane, (±)-1,2-Bis(3,5-dioxopiperazinyl)propane, 1,2-Bis(3,5-dioxo-1-piperazinyl)propane, 4,4′-Propylenebis(2,6-piperazinedione), ICI 59118, ICRF 159, NSC 129943, Razoxin, Tepirone, Troxozone
• Empirical Formula (Hill Notation): C₁₁H₁₆N₄O₄
• CAS Number: 21416-67-1
• Molecular Weight: 268.27
• EC Number: 244-379-2
• MDL number: MFCD00430424
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824039
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: >98% (HPLC)
• form: solid
• solubility: DMSO: 40 mg/mL
• storage temp.: room temp
• SMILES string: CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
• InChI: 1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)
• InChI key: BMKDZUISNHGIBY-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Razoxane is clinically active against angiogenesis and metastasis. Razoxane specifically inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor). It is an antimitotic agent with immunosuppressive properties. Razoxane inhibits blood-borne and lymphatic metastases in different experimental models. Studies have shown that razoxane inhibits specifically the vasculogenic mimicry of B16F10 melanoma cells.

Razoxane is clinically active against angiogenesis and metastasis; inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable