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SAB3500199

Sigma-Aldrich

Anti-Clusterin antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-ApoJ, Anti-Apolipoprotein J, Anti-CLI, Anti-Complement lysis inhibitor

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100 μG
₹59,466.00

About This Item

MDL number:
MFCD01092275
UNSPSC Code:
12352203
NACRES:
NA.41

₹59,466.00

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

NP_001822

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Anti-Clusterin antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

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Anti-Clusterin antibody produced in rabbit

Monoclonal Anti-CLU antibody produced in mouse clone 1A11, purified immunoglobulin, buffered aqueous solution

WH0001191M1

Monoclonal Anti-CLU antibody produced in mouse

Anti-CLU antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

HPA000572

Anti-CLU antibody produced in rabbit

Anti-FEM1C antibody produced in goat affinity isolated antibody, buffered aqueous solution

SAB2500391

Anti-FEM1C antibody produced in goat

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

biological source

rabbit

biological source

mouse

biological source

rabbit

biological source

goat

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Gene Information

human ... CLU(1191)

Gene Information

human ... CLU(1191)

Gene Information

human ... CLU(1191)

Gene Information

human ... FEM1C(56929)

species reactivity

human, mouse

species reactivity

human

species reactivity

human

species reactivity

human, mouse

General description

The Clusterin (CLU) gene is mapped to human chromosome 8p21.1. The encoded protein is a chaperone and is conserved along with evolution. It is present in human tissues and fluids.

Immunogen

Clusterin antibody was raised recombinant human Clusterin isoform 1.

Application

Anti-Clusterin antibody produced in rabbit has been used in immunohistochemical (IHC) staining (1:1,000 & 1:100).[1][2]

Biochem/physiol Actions

Clusterin (CLU) is a multifunctional plasma protein and a fluid-phase complement inhibitor. It mediates the complement terminal pathway. Clusterin is an ATP-independent small heat shock protein-like chaperone. It functions as a redox sensor and a lipid transporter. Clusterin is associated with many age-related diseases such as neurodegeneration and metabolic syndrome. It is involved in cancer progression, promotion, metastasis, and chemoresistance. Increased serum CLU levels are observed in type 2 diabetes (T2D). It is known to suppress proteotoxicity. Clusterin might show anti or proapoptotic activities. This protein is associated with different functions of the brain. A single nucleotide polymorphism (SNP) in the CLU gene might cause the development of late-onset Alzheimer′s disease (LOAD).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    38560504

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    Katina M Athanas et al.
    Schizophrenia research, 169(1-3), 381-385 (2015-10-21)
    The expression of the gene that encodes clusterin, a glycoprotein that has been implicated in the regulation of many cellular processes, has previously been found in gene expression profiling studies to be among the most significantly differentially expressed genes in
    Prakash Priyadarshi Praharaj et al.
    Biochimica et biophysica acta. Reviews on cancer, 1875(2), 188500-188500 (2021-01-02)
    Clusterin (CLU) is an evolutionary conserved molecular chaperone present in different human tissues and fluids and established to be a significant cancer regulator. It controls several cancer-associated cellular events, including cancer cell proliferation, stemness, survival, metastasis, epithelial-mesenchymal transition, therapy resistance
    Martina Zandl-Lang et al.
    Biochimica et biophysica acta, 1863(1), 40-60 (2017-09-25)
    Amyloid-β peptides (Aβ) accumulate in cerebral capillaries indicating a central role of the blood-brain barrier (BBB) in the pathogenesis of Alzheimer's disease (AD). Although a relationship between apolipoprotein-, cholesterol- and Aβ metabolism is evident, the interconnecting mechanisms operating in brain
    Joanna Stafiej et al.
    Experimental and therapeutic medicine, 13(3), 1057-1063 (2017-04-30)
    Pseudoexfoliation syndrome (PEX) is an age-associated, sight disorder affecting elastic fibers in the eye and visceral organs but its exact etiology remains unknown. The purpose of the current study was to determine the morphology and ultrastructure of lens epithelial cells
    Koichi Shoji et al.
    Oncology reports, 32(1), 65-70 (2014-05-21)
    Fibroblast growth factor receptor 2 (FGFR2) is thought to mediate an important signaling pathway between prostate epithelial cells and stromal cells for maintenance of homeostasis in normal prostate tissue. Abnormalities of FGFR2 have been shown in advanced prostate cancer or

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