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Key Documents

SML0360

Sigma-Aldrich

TAK-715

≥98% (HPLC)

Synonym(s):

N-(4-(2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide

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About This Item

Empirical Formula (Hill Notation):
C24H21N3OS
CAS Number:
Molecular Weight:
399.51
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

faintly yellow to dark yellow

solubility

DMSO: >15 mg/mL

storage temp.

2-8°C

SMILES string

CCc1nc(-c2cccc(C)c2)c(s1)-c3ccnc(NC(=O)c4ccccc4)c3

InChI

1S/C24H21N3OS/c1-3-21-27-22(18-11-7-8-16(2)14-18)23(29-21)19-12-13-25-20(15-19)26-24(28)17-9-5-4-6-10-17/h4-15H,3H2,1-2H3,(H,25,26,28)

InChI key

HEKAIDKUDLCBRU-UHFFFAOYSA-N

Gene Information

human ... MAPK14(1432)

Biochem/physiol Actions

TAK-715 is a dual p38 MAPK and CKId/e inhibitor; inhibitor of Wnt-3a-stimulated β-catenin signaling.
TAK-715 is a potent p38 inhibitor that also inhibits CKId/e (casein kinase Id/e), known activator of Wnt/β-catenin signaling.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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