SML1976

DIM-C-pPhCO2Me

≥98% (HPLC)

• Synonym(s): 4-(di-1H-Indol-3-ylmethyl)-benzoic acid methyl ester, Benzoic acid, 4-(di-1H-indol-3-ylmethyl)-, methyl ester
• Empirical Formula (Hill Notation): C₂₅H₂₀N₂O₂
• CAS Number: 151358-48-4
• Molecular Weight: 380.44
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: pink to light red
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(OC)C1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=CC=CC=C54)C=C1
• InChI: 1S/C25H20N2O2/c1-29-25(28)17-12-10-16(11-13-17)24(20-14-26-22-8-4-2-6-18(20)22)21-15-27-23-9-5-3-7-19(21)23/h2-15,24,26-27H,1H3
• InChI key: BBAOKSZCULLDIW-UHFFFAOYSA-N

Description

Biochem/physiol Actions

DIM-C-pPhCO2Me is a NR4A1 (Nur77) antagonist that exhibit potent anticancer activity in pancreatic, colon, breast, kidney, and rhabdomyosarcoma cells. DIM-C-pPhCO2Me decreases expression of PAX3-FOXO1A and β1-integrin proteins in Rh30 rhabdomyosarcoma and MDA-MB-231 breast cancer cells. DIM-C-pPhCO2Me inhibits migration of Rh30 and MDA-MB-231 cancer cells.

DIM-C-pPhCO₂Me is also known as 1,1-bis(3′-indolyl)-1-(p-carboxymethylphenyl)methane. In pancreatic and colon cancer cells, DIM-C-pPhCO₂Me plays an inhibitory role on cell migration. DIM-C-pPhCO₂Me prevents the action of mechanistic target of rapamycin (mTOR) and reduces the multiplication and survival of cancer cells. It stimulates reactive oxygen species (ROS) in various cancer cell lines.

NR4A1 (Nur77) antagonist that exhibit potent anticancer activity

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable