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SML2465

Sigma-Aldrich

CY-09

≥98% (HPLC)

Synonym(s):

4-[[4-Oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]benzoic acid

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143,00 $
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574,00 $

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5 MG
143,00 $
25 MG
574,00 $

About This Item

Empirical Formula (Hill Notation):
C19H12F3NO3S2
CAS Number:
1073612-91-5
Molecular Weight:
423.43
MDL number:
MFCD31714171
UNSPSC Code:
12352200
NACRES:
NA.77

143,00 $

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Assay

≥98% (HPLC)

form

powder

color

faint yellow to dark orange

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC(C(C=C1)=CC=C1/C=C(SC2=S)\C(N2CC3=CC=CC(C(F)(F)F)=C3)=O)=O

InChI

1S/C19H12F3NO3S2/c20-19(21,22)14-3-1-2-12(8-14)10-23-16(24)15(28-18(23)27)9-11-4-6-13(7-5-11)17(25)26/h1-9H,10H2,(H,25,26)/b15-9+

InChI key

DJTINRHPPGAPLD-OQLLNIDSSA-N

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CY-09 ≥98% (HPLC)

SML2465

CY-09

BAY 60-2770 ≥98% (HPLC)

SML2281

BAY 60-2770

Jedi1 ≥98% (HPLC)

SML2533

Jedi1

YM-1

SML0943

YM-1

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 2 mg/mL, clear (warmed)

color

faint yellow to dark orange

color

white to beige

color

white to beige

color

orange to dark red

Biochem/physiol Actions

CY-09 is an NLRP3 inflammasone inhibitor. CY-09 binds directly to the ATP-binding motif of NLRP3 NACHT domain and inhibits its ATPase activity, blocking NLRP3 inflammasome assembly and activation. In mouse models CY-09 showed therapeutic effects in type 2 diabetes and cryopyrin-associated auto-inflammatory syndrome (CAPS), which is caused by gain-of-function mutations of NLRP3.
NLRP3 inflammasome inhibitor

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Matthew S J Mangan et al.
    Nature reviews. Drug discovery, 17(8), 588-606 (2018-07-22)
    Danger signals are a hallmark of many common inflammatory diseases, and these stimuli can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR- and pyrin domain-containing 3). Once activated, NLRP3 nucleates the assembly of an inflammasome, leading
    Jianlin Qiao et al.
    Haematologica, 103(9), 1568-1576 (2018-05-26)
    In addition to their hemostatic function, platelets play an important role in regulating the inflammatory response. The platelet NLRP3 inflammasome not only promotes interleukin-1β secretion, but was also found to be upregulated during platelet activation and thrombus formation in vitro
    Hua Jiang et al.
    The Journal of experimental medicine, 214(11), 3219-3238 (2017-10-13)
    The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety of human diseases. A few compounds have been developed to inhibit NLRP3 inflammasome activation, but compounds directly and specifically targeting NLRP3 are still not available, so it

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