SML2587
AQ1 trifluoroacetic acid salt
≥98% (HPLC)
Synonym(s):
2,2′-(9,10-dihydro-9,10-dioxo-1,5-anthracenediyl)bis[L-lysyl-β-alaninamide trifluoroacetic acid
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About This Item
Empirical Formula (Hill Notation):
C32H44N8O6 · xC2HF3O2
CAS Number:
Molecular Weight:
636.74 (free base basis)
UNSPSC Code:
12352106
NACRES:
NA.77
Recommended Products
Assay
≥98% (HPLC)
form
powder
color
faint yellow to dark orange
solubility
H2O: 2 mg/mL, clear
storage temp.
−20°C
Biochem/physiol Actions
AQ1, an anthraquinone derivative, is a potent stabilizer of c-KIT G-quadruplexes (G4) that downregulates c-KIT mRNA and protein expression in human and canine cell lines. Also, AQ1 causes inhibition BCL2 gene expression in HGC27 and MCF7 cells. AQ1 inhibits proliferation of in varies human tumor cell lines including HCG27, MCF7 and imatinib resistant HMC1.2 cells.
potent stabilizer of c-KIT G-quadruplexes (G4) that downregulates c-KIT mRNA and protein expression; KIT transcriptional down-regulator
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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