Name: AS3334034
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₂N₄O₃S

CAS Number:

2724942-14-5

Molecular Weight:

374.46

UNSPSC Code:

12352200

NACRES:

NA.77

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CC1=CNN=C1NC2=CC=NC3=CC(OC)=C(S(=O)(C(C)(C)C)=O)C=C32

InChI

1S/C18H22N4O3S/c1-11-10-20-22-17(11)21-13-6-7-19-14-9-15(25-5)16(8-12(13)14)26(23,24)18(2,3)4/h6-10H,1-5H3,(H2,19,20,21,22)

InChI key

WCPMUQAUSFXFJE-UHFFFAOYSA-N

Biochem/physiol Actions

AS3334034 is an orally available, potent and selective RIP2 (Receptor-interacting protein kinase 2) inhibitor that exhibits renoprotective effects in uninephrectomized adriamycin-induced CKD (chronic kidney disease) rats. It appears that AS3334034 suppresses the progression of chronic renal failure via an anti-inflammatory effect.

Orally available, potent and selective RIP2 inhibitor that exhibits renoprotective effects

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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