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SML3067

Sigma-Aldrich

WM-1119

≥98% (HPLC)

Synonym(s):

2-Fluoro-N′-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide, 3-Fluoro-N′-(2-fluorophenyl)sulfonyl-5-(2-pyridyl)benzohydrazide, WM 1119, WM1119

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15 MG
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15 MG
CA$2,000.00

About This Item

Empirical Formula (Hill Notation):
C18H13F2N3O3S
CAS Number:
Molecular Weight:
389.38
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

CA$2,000.00


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Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC1=CC(C2=NC=CC=C2)=CC(C(NNS(C3=CC=CC=C3F)(=O)=O)=O)=C1

InChI

1S/C18H13F2N3O3S/c19-14-10-12(16-6-3-4-8-21-16)9-13(11-14)18(24)22-23-27(25,26)17-7-2-1-5-15(17)20/h1-11,23H,(H,22,24)

InChI key

QLXULUNLCRKWRD-UHFFFAOYSA-N

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form

foil

form

foil

form

foil

form

foil

manufacturer/tradename

Goodfellow 236-502-08

manufacturer/tradename

Goodfellow 706-275-29

manufacturer/tradename

Goodfellow 242-036-07

manufacturer/tradename

Goodfellow 534-937-45

assay

99.95%

assay

99.95%

assay

99.95%

assay

99.95%

resistivity

1.673 μΩ-cm, 20°C

resistivity

1.673 μΩ-cm, 20°C

resistivity

1.673 μΩ-cm, 20°C

resistivity

1.673 μΩ-cm, 20°C

density

8.94 g/mL at 25 °C (lit.)

density

8.94 g/mL at 25 °C (lit.)

density

8.94 g/mL at 25 °C (lit.)

density

8.94 g/mL at 25 °C (lit.)

mp

1083.4 °C (lit.)

mp

1083.4 °C (lit.)

mp

1083.4 °C (lit.)

mp

1083.4 °C (lit.)

Biochem/physiol Actions

Potent and selective, acetyl-CoA-competitive MYST family histone acetyltransferases KAT6A and KAT6B inhibitor with anti-cancer efficacy in vitro and in vivo.
WM-1119 is a potent and selective, acetyl coenzyme A (Acetyl-CoA)-competitive inhibitor against MYST family histone acetyltransferases KAT6A and KAT6B (KAT6B Kd = 2.1 nM by SPR, IC50 = 37 nM by activity assay; KAT7/5 Kd = 0.53/2.2 μM; no affinity toward 159 diverse biological targets). WM-1119 induces MEF G1 cell cycle arrest (1-10 μM), inhibits EMRK1184 lymphoma growth in cultures (IC50 = 250 nM) and in mice in vivo (50 mg/kg 3x or 4x i.p. per day).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Donita C Brady et al.
Nature, 509(7501), 492-496 (2014-04-11)
The BRAF kinase is mutated, typically Val 600→Glu (V600E), to induce an active oncogenic state in a large fraction of melanomas, thyroid cancers, hairy cell leukaemias and, to a smaller extent, a wide spectrum of other cancers. BRAF(V600E) phosphorylates and
Hiroki Serizawa et al.
Organic letters, 16(13), 3456-3459 (2014-06-14)
The direct synthesis of pentafluoroethyl copper (CuC2F5) from a cuprate reagent and ethyl pentafluoropropionate as one of the most economical and useful pentafluoroethyl sources was accomplished. The advantages of this method are; all the reagents employed are low-cost and operationally
Gwilherm Evano et al.
Natural product reports, 30(12), 1467-1489 (2013-10-25)
Copper-catalyzed Ullmann-Goldberg-type cross-coupling reactions have undergone nothing short of a renaissance over the last decade and an impressive number of procedures are now available for the formation of C-N, C-O and C-S bonds with remarkable efficiencies and surgical precision. These
Nathalie Adam et al.
Environmental pollution (Barking, Essex : 1987), 194, 130-137 (2014-08-12)
In this study the uptake of ZnO and CuO nanoparticles by Daphnia magna was tested. Daphnids were exposed during 48 h to acute concentrations of the nanoparticles and corresponding metal salts. The Daphnia zinc and copper concentration was measured and the
Marta Ugarte et al.
Survey of ophthalmology, 58(6), 585-609 (2013-10-29)
The essential trace metals iron, zinc, and copper play important roles both in retinal physiology and disease. They are involved in various retinal functions such as phototransduction, the visual cycle, and the process of neurotransmission, being tightly bound to proteins

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