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SML3185

Sigma-Aldrich

CGP 48664 dihydrochloride

≥98% (HPLC)

Synonym(s):

(E)-2-(4-carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazine-1-carboximidamide dihydrochloride, (E)-2-[4-(Aminoiminomethyl)-2,3-dihydro-1H-inden-1-ylidene]hydrazinecarboximidamide dihydrochloride, 4-Amidino-1-indanone-2′-amidinohydrazone dihydrochloride, 4-Amidinoindan-1-one-2?-amidinohydrazone dihydrochloride, CGP 48664A dihydrochloride, CGP48664 dihydrochloride, CMA 48664 dihydrochloride, SAM486A dihydrochloride, Sardomozide dihydrochlorid, Sardomozide dihydrochloride

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20 MG
1 750,00 $

1 750,00 $

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20 MG
1 750,00 $

About This Item

Empirical Formula (Hill Notation):
C11H14N6 · 2HCl
CAS Number:
138794-73-7
Molecular Weight:
303.19
MDL number:
MFCD00910325
UNSPSC Code:
12352200
NACRES:
NA.77

1 750,00 $

Please contact Customer Service for Availability
Request a Bulk Order
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Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

NC(C1=CC=CC2=C1CC/C2=N\NC(N)=N)=N.Cl.Cl

InChI

1S/C11H14N6/c12-10(13)8-3-1-2-7-6(8)4-5-9(7)16-17-11(14)15/h1-3H,4-5H2,(H3,12,13)(H4,14,15,17)/b16-9+

InChI key

CYPGNVSXMAUSJY-CXUHLZMHSA-N

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technique(s)

SDS-PAGE: suitable, immunoblotting: suitable, electrophoresis: suitable, western blot: suitable

technique(s)

SDS-PAGE: suitable, electrophoresis: suitable, immunoblotting: suitable, western blot: suitable

technique(s)

-

technique(s)

electrophoresis: suitable, immunoblotting: suitable, western blot: suitable

shelf life

12 mo.

shelf life

12 mo.

shelf life

-

shelf life

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

packaging

kit of 1 kit (~75 gels)

packaging

1 ea of 1 ea

packaging

-

packaging

1 ea of 1 ea

manufacturer/tradename

Millipore

manufacturer/tradename

Millipore

manufacturer/tradename

-

manufacturer/tradename

Millipore

Biochem/physiol Actions

CGP 48664 (SAM486A; Sardomozide) is a polyamine (PA) biosynthesis inhibitor (73% and 97% downregulation of murine leukemia L1210 cellular spermidine and spermine, respectively, by 0.5 μM Sardomozide in 4 days) that targets the rate-limiting enzyme S-adenosylmethionine decarboxylase (AdoMetDC, SAMDC, AMD1) in a potent (IC50 = 5 nM against rat AMD1) and selective manner with little or no inhibitory efficacy toward diamine oxidase or ornithine decarboxylase (IC50 = 18 μM and >50 μM against rat DAO and ODC, respectively). CGP 48664 effectively inhibits the proliferation of murine (GI50 = 0.5 μM against L1210 in 4 days) and human cancer cell lines in cultures (GI50 from 0.26 to 0.6 μM in 5 days; GI50 = 0.8 μM against human melanoma SK MEL-24 in 10 days) and suppresses the growth of murine and human tumor xenografts in mice in vivo (ED50 ≤0.5 mg/kg i.p.). CGP 48664 (Sardomozide) potently inhibits growth of PFA ependymoma cells.
Potent and selective S-adenosylmethionine decarboxylase (AdoMetDC, SAMDC, AMD1) inhibitor with anti-cancer efficacy both in vitro and in vivo.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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