biological source
Toxoplasma gondii
recombinant
expressed in E. coli
Assay
>95% (SDS-PAGE)
form
lyophilized
mol wt
~20 kDa by SDS-PAGE
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
<0.01 EU/μg endotoxin, tested
color
white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
Toxoplasma gondii ... PRF(7900190)
Biochem/physiol Actions
Profilin is a protozoan parasite protein. It activates toll-like receptor 11 (TLR11), which is an intracellular receptor localized on the endoplasmic reticulum (ER). TLR11 acts as an innate immune sensor for T. gondii profilin (TgPRF).The 12 membrane-spanning ER-resident protein UNC93B1 directly binds TLR11 and control the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12 also has an ability to interact with (TgPRF). TLR12 is adequate for recognizing profilin in plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both needed in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice fail to resist T. gondii infection.
Physical form
Lyophilized from PBS.
Reconstitution
Reconstitute with 100 μL deionized water.
Other Notes
Recombinant profilin (Toxoplasma gondii) (aa 1-163).
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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