Amorphous Stability & Mesoporous Silica

WEBINAR

Historically, polymeric solid dispersions have been the technology of choice for amorphous formulation. However, this approach may have some downfalls when considering the ability to stabilize compounds in the amorphous form, especially poor glass former compounds with a high propensity to re-crystallize. This webinar will examine amorphous stability from a theoretical perspective in the context of polymeric solid dispersions and mesoporous silica formulations. Finally, we will present recent data demonstrating the potential of mesoporous silica for superior amorphous stabilization of poor glass formers.

In this webinar, you will learn:

• Why amorphous stability is a critical consideration in formulation development for poorly soluble compounds
• How amorphous stability can be assessed using the glass-forming ability
• Why poor glass former compounds can be challenging to formulate with traditional polymeric solid dispersions
• How mesoporous silica can stabilize poor glass formers via nanoconfinement and reduction in molecular mobility