Diethoxy(3-glycidyloxypropyl)methylsilane (GPMS) is an epoxysilane which can be used as a silane coupling agent for the surface treatment of a variety of materials. These silanes can also be used as adhesion promoters by modifying the surface properties of the substrates and elastomeric materials.

Coverslips coated with diethoxy(3-glycidyloxypropyl)methyl silane were used as sample holders for electrostatically holding particles for optical microscopy.{52} It may be used to introduce epoxy groups to Fe₃O₄SiO₂ nanoparticles. {53} Self assembled monolayer (SAMs) of diethoxy(3- glycidyloxypropyl)methylsilane could be formed on the oxide layer of silicon wafer to render them siloxane functionalities.{54}

GPMS can be used in the surface modification of a variety of particles such as cellulose nanocrystals, silica nanomaterials and other silicon based substrates. It functionalizes these surfaces by attaching the epoxy-silane groups with the surface molecules.