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About This Item
Empirical Formula (Hill Notation):
C9H13ClNO3P
CAS Number:
Molecular Weight:
249.63
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32
form
solid
Quality Level
impurities
≥97% (NMR)
color
white
solubility
0.1 M HCl: 13.3 mg/mL
methanol: 19.3 mg/mL
DMSO: insoluble
SMILES string
NCC(CP(O)(O)=O)c1ccc(Cl)cc1
InChI
1S/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14)
InChI key
VSGNGLJPOGUDON-UHFFFAOYSA-N
Gene Information
human ... GABBR1(2550), GABBR2(9568)
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General description
Phaclofen is a phosphonic acid derivative of baclofen.
Application
Phaclofen has been used to block GABAB receptor.
Biochem/physiol Actions
Phaclofen plays a vital role in identifying the physiological importance of central and peripheral bicuculline-insensitive receptors with which GABA and (−) baclofen interact. Phaclofen acts as a GABAB receptor antagonist. Phaclofen has an ability to reversibly block the late, bicuculline resistant, K+ dependent inhibitory postsynaptic potential (IPSP) logged in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurons.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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