Unlocking Bioavailability: Mesoporous Drug Carrier for Stable Amorphous Formulations

WEBINAR

Drug solubility is a critical issue in formulation development, with many compounds facing risks due to poor oral bioavailability. Enhancing solubility is a major challenge for both new chemical entities and existing drugs. Mesoporous silica offers a solution by utilizing molecular adsorption and steric stabilization within its nanoconfined pores, to create stable and effective amorphous formulations. This approach is promising for improving the bioavailability of poorly soluble active pharmaceutical ingredients (APIs). The session will cover the mechanistic foundations of mesoporous silica, including lab-scale loading and scale-up potential, along with in vitro and in vivo case studies demonstrating its effectiveness for typical BCS II compounds.

In this webinar, you will learn:

• An overview how mesoporous silica technology result in stable and effective amorphous formulations
• Loading methods on mesoporous silica and their performance
• Case studies of in vitro and in vivo performance of mesoporous silica formulations
• How mesoporous silica can reduce the risk of re-crystallization of poor glass formers.