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HLA-C

major histocompatibility complex, class I, C

Synonyms:
D6S204, HLA-JY3, HLC-C, PSORS1
Species:
Human HLA-C (3107)
UniProtKB ID:
P10321, O78061, O78083, Q29631, Q29652, Q29867, Q29990, Q95463
Gene ID:
  • Human(3107) Summary: HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008]

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB1405938
Anti-HLA-C antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
MABF233
Anti-HLA-C Antibody, clone DT9, clone DT9, from mouse,
Species Reactivity
human
Application
flow cytometry
immunoprecipitation (IP)
SAB2107752
Anti-HLA-C antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, pig, rabbit
Application
western blot
SAB4700636
Monoclonal Anti-HLA Class I-PE antibody produced in mouse, clone MEM-147, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
flow cytometry
SAB4700637
Monoclonal Anti-HLA Class I, low endotoxin antibody produced in mouse, clone W6/32, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
flow cytometry