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PIK3R1

phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

Synonyms:
AGM7, GRB1, p85, p85-ALPHA
Species:
Human PIK3R1 (5295), Mouse Pik3r1 (18708), Rat Pik3r1 (25513), Zebrafish pik3r1 (557176), chicken PIK3R1 (427171), domestic cat PIK3R1 (100271864), dog PIK3R1 (487235), cow PIK3R1 (282307), sheep PIK3R1 (101121455), domestic guinea pig Pik3r1 (100730242)
UniProtKB ID:
P27986, B3KT19, D3DWA0, E7EX19, Q15747, Q4VBZ7, Q53EM6, Q8IXA2
Gene ID:
  • Human(5295) Summary: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
  • Mouse(18708) phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
  • Rat(25513) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • Zebrafish(557176) phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)
  • chicken(427171) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • domestic cat(100271864) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • dog(487235) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • cow(282307) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • sheep(101121455) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • domestic guinea pig(100730242) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

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Antibodies

Product Number
Description
Species Reactivity
Application
HPA001216
Anti-PIK3R1 antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
05-212
Anti-PI3 Kinase Antibody, p85, N-SH3, clone AB6, clone AB6, Upstate®, from mouse,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunoprecipitation (IP)
western blot
MABS831
Anti-PI3 Kinase Antibody, p85 Antibody, N-SH3 Antibody, clone 1D5.1, clone 1D5.1, from mouse,
Species Reactivity
human, mouse
Application
western blot
ABS1856
Anti-PI3 Kinase Antibody, p85, from rabbit, purified by affinity chromatography,
Species Reactivity
bovine, human, mouse, rat, rhesus monkey
Application
immunoprecipitation (IP)
western blot
SAB5700508
Anti-Phospho-PI3KP85α/γ/β-Y467/Y199/Y464 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
W1628
Wortmannin, from Penicillium funiculosum, ≥98% (HPLC and TLC),
Species
human
W3144
Wortmannin, Ready Made Solution, from Penicillium funiculosum, ≥95% (HPLC),
Species
human
D2926
Diphenyleneiodonium chloride, ≥98%,
Species
mouse, human
PZ0235
PF-04691502, ≥98% (HPLC),
Species
human

esiRNA

Product Number
Description
Species
EHU151811
MISSION® esiRNA, targeting human PIK3R1,
Species
human
EMU187151
MISSION® esiRNA, targeting mouse Pik3r1,
Species
mouse