132195

Trimethyl phosphate

97%

• Synonym(s): TMP, TMPA, TMPO
• Linear Formula: (CH₃O)₃PO
• CAS Number: 512-56-1
• Molecular Weight: 140.07
• Beilstein/REAXYS Number: 1071731
• EC Number: 208-144-8
• MDL number: MFCD00008348
• UNSPSC Code: 12352100
• PubChem Substance ID: 24847552
• NACRES: NA.22

Properties

• Quality Level: 200
• assay: 97%
• form: liquid
• refractive index: n20/D 1.395 (lit.)
• bp: 197 °C (lit.)
• mp: −46 °C (lit.)
• density: 1.197 g/mL at 25 °C (lit.)
• functional group: phosphate
• SMILES string: COP(=O)(OC)OC
• InChI: 1S/C3H9O4P/c1-5-8(4,6-2)7-3/h1-3H3

Description

General description

Trimethyl phosphate is an excellent dipolar aprotic solvent that is used as a methylating agent and acid scavenger in many organic transformations.

Application

Trimethyl phosphate can be used as a methylating agent for the:

• Solvent-free o-methylation of phenolic compounds to synthesize methyl aryl ethers.
• S-methylation of aryl/alkyl thiols to synthesize S-methylated product in the presence of Ca(OH)₂ as a base.

Safety Information

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H315,H319,H340,H351
• pcodes: P202 - P264 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 1
• flash_point_f: 302.0 °F - closed cup
• flash_point_c: 150 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter