W225207

β-Caryophyllene

≥80%, FCC, FG

• Synonym(s): (−)-trans-Caryophyllene, trans-(1R,9S)-8-Methylene-4,11,11-trimethylbicyclo[7.2.0]undec-4-ene
• Empirical Formula (Hill Notation): C₁₅H₂₄
• CAS Number: 87-44-5
• Molecular Weight: 204.35
• FEMA Number: 2252
• Beilstein/REAXYS Number: 2044564
• EC Number: 201-746-1
• Council of Europe no.: 2618
• MDL number: MFCD00075925
• UNSPSC Code: 12164502
• PubChem Substance ID: 24900952
• Flavis number: 1.007
• NACRES: NA.21
• Organoleptic: spicy; woody
• Grade: FG; Fragrance grade; Halal; Kosher
• Biological source: synthetic
• Agency: follows IFRA guidelines; meets purity specifications of JECFA
• Food allergen: no known allergens

Properties

• biological source: synthetic
• Quality Level: 300; 400
• grade: FG; Fragrance grade; Halal; Kosher
• agency: follows IFRA guidelines; meets purity specifications of JECFA
• reg. compliance: EU Regulation 1223/2009; EU Regulation 1334/2008 & 178/2002; FCC; FDA 21 CFR 117; FDA 21 CFR 172.515
• assay: ≥80%
• optical activity: [α]23/D −7.5°, neat
• composition: contains β-Caryophyllene
• refractive index: n20/D 1.5 (lit.)
• bp: 129-130 °C/14 mmHg (lit.)

Description

General description

β;-Caryophyllene is a volatile sesquiterpene compound that can be used as a flavoring agent. It is one of the major volatile organic compounds in Eugenia caryophyllata essential oil, Psidium guajava L. leaves, Arabidopsis thaliana flowers and Artemisia annua L. aerial parts.

Application

• Essential Oil Constituents as Anti-Inflammatory and Neuroprotective Agents: An Insight through Microglia Modulation.: ß-Caryophyllene shows significant potential as an anti-inflammatory and neuroprotective agent by modulating microglia, which plays a crucial role in neuroinflammation (Stojanovic et al., 2024) (Stojanovic et al., 2024).


• Synergistic Antinociceptive Effect of ß-Caryophyllene Oxide in Combination with Paracetamol, and the Corresponding Gastroprotective Activity.: This research demonstrates that ß-caryophyllene oxide, when combined with paracetamol, has enhanced antinociceptive effects and provides gastroprotection (Espinosa-Juárez et al., 2024) (Espinosa-Juárez et al., 2024).


• Consumption of ß-Caryophyllene Increases the Mating Success of Bactrocera zonata Males (Diptera: Tephritidae).: The study explores how ß-caryophyllene consumption boosts the mating success of male fruit flies, indicating its potential applications in pest control strategies (Ul Haq et al., 2024) (Ul Haq et al., 2024).


• Development of ophthalmic nanoemulsions of ß-caryophyllene for the treatment of Acanthamoeba keratitis.: This research focuses on creating nanoemulsions containing ß-caryophyllene for treating Acanthamoeba keratitis, demonstrating its potential in ophthalmic therapies (Santos Porto et al., 2024) (Santos Porto et al., 2024).

Safety Information

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H304,H317
• pcodes: P261 - P272 - P280 - P301 + P310 - P302 + P352 - P331
• Hazard Classifications: Asp. Tox. 1 - Skin Sens. 1B
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: 221.9 °F - closed cup
• flash_point_c: 105.5 °C - closed cup
• ppe: Eyeshields, Gloves