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M-072

Supelco

Metformin hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C4H12ClN5
CAS Number:
1115-70-4
Molecular Weight:
165.62
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24
Pricing and availability is not currently available.

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

format

single component solution

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This Item
1396309M0605000BP227
Metformin hydrochloride solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

M-072

Metformin hydrochloride solution

Metformin hydrochloride United States Pharmacopeia (USP) Reference Standard

1396309

Metformin hydrochloride

Metformin hydrochloride European Pharmacopoeia (EP) Reference Standard

M0605000

Metformin hydrochloride

Metformin hydrochloride British Pharmacopoeia (BP) Reference Standard

BP227

Metformin hydrochloride

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

-

technique(s)

-

technique(s)

-

form

liquid

form

-

form

-

form

crystalline

format

single component solution

format

neat

format

neat

format

neat

Quality Level

300

Quality Level

-

Quality Level

-

Quality Level

-

grade

certified reference material

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

General description

A Snap-N-Spike® reference solution applicable to use in clinical toxicology by LC-MS/MS or GC/MS. Metformin is an antidiabetic drug which functions by suppressing liver production of glucose. This biguanide analog is used specifically for treatment of type 2 diabetes.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

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    L C Morin-Papunen et al.
    The Journal of clinical endocrinology and metabolism, 85(9), 3161-3168 (2000-09-22)
    Metformin, a biguanide antihyperglycemic drug, has been shown to improve ovarian function and glucose metabolism in women with polycystic ovary syndrome (PCOS), but results concerning its effects on insulin sensitivity are controversial. Oral contraceptive pills are commonly used in the
    P H Marathe et al.
    British journal of clinical pharmacology, 50(4), 325-332 (2000-09-30)
    The purpose of this in vivo human study was to assess the effect of altered gastric emptying and gastrointestinal motility on the absorption of metformin in healthy subjects. An open-label, three treatment, three period crossover study was conducted in 11
    J De Jager et al.
    Journal of internal medicine, 257(1), 100-109 (2004-12-21)
    The UK Prospective Diabetes Study (UKPDS) showed that treatment with metformin decreases macrovascular morbidity and mortality independent of glycaemic control. We hypothesized that metformin may achieve this by improving endothelial function and chronic, low-grade inflammation. Data on this issue are
    J-D Lalau et al.
    Diabetes, obesity & metabolism, 5(2), 93-98 (2003-03-13)
    Although pharmacokinetics studies have long suggested a deep compartment for the antidiabetic drug metformin, there is still little information concerning metformin accumulation by individual tissues in man. In the present study, the erythrocyte was chosen to represent this putative deep
    P S Gillies et al.
    Drugs, 60(2), 333-343 (2000-09-13)
    Pioglitazone is an orally administered insulin sensitising thiazolidinedione agent that has been developed for the treatment of type 2 diabetes mellitus. Pioglitazone activates the nuclear peroxisome proliferator activated receptor-gamma (PPAR-gamma), which leads to the increased transcription of various proteins regulating
    View All Related Papers

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