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AB5580

Sigma-Aldrich

Anti-SCN8A Sodium Channel Antibody

Chemicon®, from rabbit

Synonym(s):

Sodium Channel Nav1.6, NaCh6, PN4, CerIII

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, mouse

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_014191.2

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8.010591.157541.01093
Aluminium triisopropylate for synthesis

8.01079

Aluminium triisopropylate

Aluminium acetylacetonate for synthesis

8.01059

Aluminium acetylacetonate

Aluminium oxide fibers for gooch crucibles

1.15754

Aluminium oxide

Aluminum hydroxide (fine powder pure, hydrargillite), Technipur®

1.01093

Aluminum hydroxide

storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

-

density

1.035 g/cm3 at 20 °C

density

-

density

-

density

2.42 g/cm3 at 20 °C

mp

130-134 °C

mp

190-193 °C

mp

>1650 °C

mp

300 °C (Elimination of water of crystallisation)

vapor pressure

0.13 hPa ( 21 °C)

vapor pressure

-

vapor pressure

-

vapor pressure

<0.1 hPa ( 20 °C)

bp

135 °C/13 hPa

bp

315 °C/1013 hPa

bp

-

bp

>2900 °C/1013 hPa

General description

Voltage-gated sodium channels perform critical roles for electrical signaling in the nervous ssystem by generating action potentials in axons and dndrites. At least 10 genes encode sodium channels in mammals, but specific physiological roles that distinguish each of these isoforms are not well known. Nav1.6 is highly concentrated at notes of Ranvier of both sensory and motor axons in the peripheral nervous system and at nodes in the central nervous system. Because of its consistant and restrictied labeling, Anti-Nav1.6 (AB5580) has been used effectively as a nodes of Ranvier marker.

Specificity

Recognizes Scn8a (Nav1.6). The epitope corresponds to the intracellular loop between II and III domains of Scn8a. Does not cross react with any other known proteins.

SPECIES REACTIVITIES: It is expected that the antibody will also work on mouse (20/20) and human (19/20) due to sequence homology. Other species have not been tested.

Immunogen

Peptide corresponding to amino acids 1042-1061 from mouse (Accession number AAD20438) or rat (Accession number AAC26014) Scn8a.

Application

Detect SCN8A Sodium Channel using this Anti-SCN8A Sodium Channel Antibody validated for use in IC, IH & WB.
Western blot: (1:200) using ECL on rat brain membranes.

Immunohistochemistry on fixed frozen sections.

Immunocytochemistry on rat dorsal root ganglion primary culture (1:100)

Dilutions should be made using a carrier protein such as BSA (1-3%)

Optimal working dilutions must be determined by the end user.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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hcodes

H412

Hazard Classifications

Aquatic Chronic 3

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

  • Specification Sheet

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