The protein named PDZK1-interacting protein 1 or alternatively 17kDa membrane-associated protein DD96 or MAP17 and encoded by the human gene named PDZK1IP1 or MAP17 is a highly unusual protein being naturally expressed only in a single epithelial cell population found in the proximal tubular epithelial cells. However, MAP17 is expressed in cancerous tissue of the kidney, colon, lung and breast. MAP17 expression in cancers causes an increase in reactive oxygen species production and tumorigenesis in cancerous tissues. These factors are mediated though MAP17’s PDZ-binding domain because disruption of this sequence by point mutations abolishes the ability of MAP17 to enhance ROS production and tumorigenesis. MAP17 also often serves as a cancer cell marker to distinguish tumor margins and tumorigenesis potential. MAP17 is a membrane bound protein and is thought to be a putative oncogene but its exact function in normal cells is still being researched.

GST-tagged recombinant protein corresponding to human MAP17.

Anti-MAP17 Antibody, clone 165C is a highly specific mouse monoclonal antibody, that targets MAP17 & has been tested in western blotting & IHC.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Western Blotting Analysis: 1.0 µg/mL from a representative lot detected MAP17 in 10 µg of human salivary gland tissue lysate.
Immunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected MAP17 in human prostate cancer and human kidney tissue.

Evaluated by Western Blotting in human kidney tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected MAP17 in 10 µg of human kidney tissue lysate.

~20 kDa observed

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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