Tyrosine-protein kinase Fgr (EC 2.7.10.2; UniProt P09769; also known as c-fgr, c-src2, c-src-2 proto-oncogene, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, p55-Fgr, p58-Fgr, p58c-Fgr, proto-oncogene c-Fgr) is encoded by the FGR (also known as SRC2) gene (Gene ID 2268) in human. Fgr is a member of the Src family of non-receptor protein tyrosine kinases (PTKs). Fgr contains N-terminal myristylation and palmitylation sites, a PTK catalytic domain, as well as SH2 and SH3 domains mediating interactions with phosphotyrosine-containing and proline-rich motifs, respectively. Fgr is a positive regulator of mast cell activation/degranulation and is essential for IgE-mediated passive cutaneous anaphylaxis (PCA) in mice. Fgr appears to act cooperatively with Fyn in the activation of Syk and its downstream targets in a manner that is counteracted by Lyn.

Recombinant protein corresponding to human Fgr.

Detect FGR using this mouse monoclonal Anti-Fgr Antibody, clone SuGr-7 14F3, Cat. No. MABS1140, validated for use in Western Blotting.

Research Category
Signaling

Research Sub Category
Signaling Neuroscience

Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Fgr in 10 µg of Ramos cell lysate.

Evaluated by Western Blotting in Daudi cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Fgr in 10 µg of Daudi cell lysate.

~59 kDa observed. Uncharacterized band(s) may appear in some lysates.

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Concentration: Please refer to lot specific datasheet.

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