PHR1381

Aspartame

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Asp-Phe methyl ester, N-(L-α-Aspartyl)-L-phenylalanine methyl ester, Asp-Phe-OMe, Aspartame
• Linear Formula: HOOCCH₂CH(NH₂)CONHCH(CH₂C₆H₅)COOCH₃
• CAS Number: 22839-47-0
• Molecular Weight: 294.30
• Beilstein/REAXYS Number: 2223850
• EC Number: 245-261-3
• MDL number: MFCD00002724
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823358
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• agency: traceable to Ph. Eur. A1320000; traceable to USP 1043706
• API family: aspartame
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(O)=O

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Aspartame is a low-calorie nutritive sugar substitute used in table-top sweeteners, chewing gums, soft drinks, etc.[1]

Application

Aspartame may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography.[2]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB9987 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable