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360376

Sigma-Aldrich

Capsaicin

63.7% (HPLC), powder, TRPV1 agonist

Synonym(s):

8-Methyl-N-vanillyl-trans-6-nonenamide

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10 EA
₹11,930.00

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10 EA
₹11,930.00

About This Item

Linear Formula:
(CH3)2CHCH=CH(CH2)4CONHCH2C6H3-4-(OH)-3-(OCH3)
CAS Number:
Molecular Weight:
305.41
Beilstein/REAXYS Number:
2816484
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

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Product Name

Capsaicin, natural

grade

natural

Quality Level

assay

63.7% (HPLC)

form

powder

composition

capsaicin, 65%
dihydrocapsaicin, 35%

mp

62-65 °C (lit.)

solubility

chloroform: 5%

storage temp.

2-8°C

SMILES string

COc1cc(CNC(=O)CCCC\C=C\C(C)C)ccc1O

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This Item
SLW1516/02DSLW1516/08DSLW1516/22D
material

borosilicate glass bottle, round bottle, polypropylene cap, white graduation

material

borosilicate glass bottle, polypropylene cap, round bottle, white graduation

material

borosilicate glass bottle, polypropylene cap, round bottle, white graduation

material

borosilicate glass bottle, polypropylene cap, round bottle, white graduation

capacity

25 mL

capacity

50 mL

capacity

500 mL

capacity

20000 mL

feature

graduations, with pouring ring, with cap, with printed trace code

feature

graduations, with cap, with pouring ring, with printed trace code

feature

graduations, with cap, with pouring ring, with printed trace code

feature

graduations, with cap, with pouring ring, with printed trace code

packaging

pack of 10 ea

packaging

pack of 10 ea

packaging

pack of 10 ea

packaging

pack of 1 ea

manufacturer/tradename

SciLabware 1516/01D

manufacturer/tradename

SciLabware 1516/02D

manufacturer/tradename

SciLabware 1516/08D

manufacturer/tradename

SciLabware 1516/22D

joint

Joints threaded neck (GL25)

joint

Joints threaded neck (GL32)

joint

Joints threaded neck (GL45)

joint

Joints threaded neck (GL45)

General description

Capsaicin (Zostrix), an alkaloid extract is obtained from hot chili peppers.[1][2] It is accessible in the form of cream and lotion.[1] Capsaicin is a hydrophobic, instable and pungent white crystalline powder, that has no smell and color. It is produced by mixing a branched-chain fatty acid to vanillylamine in the chili pepper.[3]

Application

Capsaicin has been used in the development of the isolation methods.[4] It has also been used in the development of enzyme based electrochemical biosensor for the determination of capsaicin using a novel signal amplification strategy.[5]

Biochem/physiol Actions

Capsaicin is used as an important component of oleoresin capsicum or pepper spray.[6] It plays a beneficial role in obesity, cardiovascular and gastrointestinal conditions, several cancers, neurogenic bladder and dermatologic conditions.[3] It is used in the production of spices, chilli sauces and pain-inducing defensive pepper sprays. Capsaicin is also used to manufacture creams to treat diabetic neuropathy, cluster headache, psoriasis, rheumatoid arthritis and reflex sympathetic dystrophy.[2] It is considered as an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1).[3]
Prototype vanilloid receptor agonist. Neurotoxin; activates sensory neurons that give rise to unmyelinated C-fibers, many of which contain substance P. Topical application desensitizes the sensory nerve endings giving a paradoxical antinociceptive effect; systemic administration can be neurotoxic to capsaicin-sensitive cells, especially in newborn animals. Active component of chili peppers.
Prototype vanilloid receptor agonist; neurotoxin. Active component of chili peppers.

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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