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R106

Sigma-Aldrich

Ro 16-6491 hydrochloride

solid

Synonym(s):

N-(2-Aminoethyl)-4-chlorobenzamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C9H11ClN2O · HCl
CAS Number:
94319-79-6
Molecular Weight:
235.11
MDL number:
MFCD00078595
UNSPSC Code:
12352200
PubChem Substance ID:
329823996

form

solid

color

white

mp

216-217 °C

solubility

H2O: soluble

SMILES string

Cl.NCCNC(=O)c1ccc(Cl)cc1

InChI

1S/C9H11ClN2O.ClH/c10-8-3-1-7(2-4-8)9(13)12-6-5-11;/h1-4H,5-6,11H2,(H,12,13);1H

InChI key

ARUMZUNJBHSOQQ-UHFFFAOYSA-N

Gene Information

human ... MAOB(4129)

Biochem/physiol Actions

Selective, reversible, orally-active MAO-B inhibitor which is devoid of indirect sympathomimetic activity.

comparable product

Product No.
Description
Pricing

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Xi Jun He et al.
Neurotoxicology, 29(6), 1141-1146 (2008-07-09)
Neurotoxic effects of MPTP on the nigrostriatal dopaminergic system are thought to be initiated by 1-methyl-4-phenylpyridinium (MPP+), a metabolite formed by the monoamine oxidase (MAO)-B-mediated oxidation of MPTP. We previously reported that the administration of MPTP induced apoptosis in migrating
A M Cesura et al.
Journal of neural transmission. Supplementum, 32, 165-170 (1990-01-01)
The selective, reversible inhibitors of monoamine oxidase (MAO) moclobemide and Ro 41-1049 (selective for MAO-A), as well as of Ro 16-6491 and Ro 19-6327 (selective for MAO-B) inhibited the enzyme with an initial competitive phase, followed by a time-dependent inhibition
A M Cesura et al.
European journal of pharmacology, 162(3), 457-465 (1989-03-29)
This study demonstrated the existence of specific binding sites for [3H]Ro 19-6327 in human platelet membranes. This compound is a novel, time-dependent inhibitor of monoamine oxidase type B (MAO-B) and is structurally closely related to [3H]Ro 16-6491. The density of
G E Handelmann et al.
Pharmacology, biochemistry, and behavior, 34(4), 823-828 (1989-12-01)
The N-methyl-D-aspartate receptor complex appears to play an important role in processes of learning and memory. The presence of a glycine modulatory site at this complex has recently been established and suggests that glycinergic neurotransmission may influence these cognitive functions.
H H Keller et al.
Naunyn-Schmiedeberg's archives of pharmacology, 335(1), 12-20 (1987-01-01)
The inhibition of monoamine oxidase (MAO) in rat liver and brain by the short-acting MAO-A inhibitors moclobemide (Ro 11-1163 = p-chloro-N-[2-morpholinoethyl]benzamide) and brofaremine and by the short-acting MAO-B inhibitors Ro 16-6491 (N-[2-aminoethyl]-p-chloro-benzamide) and almoxatone, administered p.o. at roughly equieffective doses
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