A0384

Arcaine sulfate salt

• Synonym(s): 1,4-Diguanidinobutane sulfate salt
• Empirical Formula (Hill Notation): C₆H₁₆N₆ · H₂O₄S
• CAS Number: 14923-17-2
• Molecular Weight: 270.31
• MDL number: MFCD00050545
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277954
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• assay: ≥98% (TLC)
• form: powder
• mp: >280 °C
• solubility: 1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• SMILES string: OS(O)(=O)=O.NC(=N)NCCCCNC(N)=N
• InChI: 1S/C6H16N6.H2O4S/c7-5(8)11-3-1-2-4-12-6(9)10;1-5(2,3)4/h1-4H2,(H4,7,8,11)(H4,9,10,12);(H2,1,2,3,4)
• InChI key: RWTGFMPOODRXIM-UHFFFAOYSA-N
• Gene Information: human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)

Description

Application

Arcaine sulfate salt has been used as an N-methyl-d-aspartate (NMDA) receptor effector/antagonist:

• to evaluate its effects on the acquisition of electrical kindling of the amygdala
• to compare its effects with agmatine and MK801 on NMDA- or glutamate-induced neuronal damage
• to study its effects on cell-free translation of synthetic polynucleotide

Biochem/physiol Actions

Arcaine sulfate salt (1,4-diguanidinobutane), a polyamine, is an antagonist of the polyamine binding site of the N-methyl-d-aspartate (NMDA) receptor. Arcaine, an agmatine analog, along with ifenprodil, might have a possibility for therapeutic management in epileptic disorders.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)