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Key Documents

AV54552

Sigma-Aldrich

Anti-UBE4B antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-E4, Anti-HDNB1, Anti-KIAA0684, Anti-UBOX3, Anti-UFD2, Anti-Ubiquitination factor E4B (UFD2 homolog, yeast)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

146 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_001099032

UniProt accession no.

O95155

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... UBE4B(10277)

General description

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.

Immunogen

Synthetic peptide directed towards the N terminal region of human UBE4B

Application

Anti-UBE4B antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.

Biochem/physiol Actions

UBE4B gene, located on chromosome 1p36, encodes a conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is one of the strongest neuroblastoma tumor suppressor genes.

Sequence

Synthetic peptide located within the following region: SPMFCSVASFGASSLSSLYESSPAPTPSFWSSVPVMGPSLASPSRAASQL

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
QC22657

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M Koegl et al.
Cell, 96(5), 635-644 (1999-03-25)
Proteins modified by multiubiquitin chains are the preferred substrates of the proteasome. Ubiquitination involves a ubiquitin-activating enzyme, E1, a ubiquitin-conjugating enzyme, E2, and often a substrate-specific ubiquitin-protein ligase, E3. Here we show that efficient multiubiquitination needed for proteasomal targeting of
Peter E Zage et al.
Cancer, 119(4), 915-923 (2012-09-20)
The UBE4B gene, which is located on chromosome 1p36, encodes a ubiquitin ligase that interacts with hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs), a protein involved in epidermal growth factor receptor (EGFR) trafficking, suggesting a link between EGFR trafficking and
Cecilia Krona et al.
Oncogene, 22(15), 2343-2351 (2003-04-18)
Deletion of a part of the short arm of chromosome 1 is one of the most common chromosomal rearrangements observed in neuroblastoma (NBL) tumors and it is associated with a poor prognosis. No NBL tumor suppressor gene has yet been

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