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B4559

Sigma-Aldrich

BRL 44408 maleate salt

≥98% (HPLC)

Synonym(s):

2-[2H-(1-Methyl-1,3-dihydroisoindole)methyl]-4,5-dihydroimidazole maleate salt

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About This Item

Empirical Formula (Hill Notation):
C17H21N3O4
CAS Number:
118343-19-4
Molecular Weight:
331.37
MDL number:
MFCD02262218
UNSPSC Code:
12352200
PubChem Substance ID:
329773239
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: soluble 15 mg/mL, clear

originator

GlaxoSmithKline

SMILES string

OC(=O)\C=C/C(O)=O.CC1N(CC2=NCCN2)Cc3ccccc13

InChI

1S/C13H17N3.C4H4O4/c1-10-12-5-3-2-4-11(12)8-16(10)9-13-14-6-7-15-13;5-3(6)1-2-4(7)8/h2-5,10H,6-9H2,1H3,(H,14,15);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

DDIQGSUEJOOQQQ-BTJKTKAUSA-N

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manufacturer/tradename

Finn 9401030

manufacturer/tradename

Finn 9400230

manufacturer/tradename

Finn 9401260

manufacturer/tradename

Finn 9402030

feature

barrier: no

feature

barrier: no

feature

barrier: no

feature

barrier: no

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

material

blue

material

colorless

material

orange

material

colorless

packaging

pack of 1000 ea (Bag)

packaging

pack of 1000 ea (Bag)

packaging

pack of 1000 ea (Bag)

packaging

pack of 500 ea (Bag)

maximum volume

1 mL

maximum volume

250 μL

maximum volume

300 μL

maximum volume

5 mL

Biochem/physiol Actions

BRL 44408 maleate is a selective α2A-adrenoceptor antagonist.

Features and Benefits

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold under agreement from Glaxo­Smith­Kline

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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    Certificates of Analysis (COA)

    Lot/Batch Number
    053M4616V
    041M4617V
    047K46245
    110M4616V
    047K46244

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    Zoltán S Zádori et al.
    Neurochemistry international, 51(5), 297-305 (2007-08-01)
    The inhibitory effect of clonidine (non-selective alpha2-adrenoceptor agonist) and oxymetazoline (alpha2A-adrenoceptor selective agonist) was compared on basal and stimulated gastric motor activity (gastric tone and contractions) using the balloon method in the rat. It was shown that oxymetazoline (0.2-1.7 micromol/kg
    Mu-huo Ji et al.
    Cytokine, 60(3), 639-645 (2012-09-11)
    To investigate the effects of α2A-adrenoreceptor blockade on acute lung injury (ALI) and high mobility group box-1 protein (HMGB1) expression in a rat model of sepsis. Sepsis was induced in male rats by cecal ligation and puncture (CLP). Thirty adult
    Junta Imaki et al.
    Neuroscience letters, 454(2), 143-147 (2009-05-12)
    We examined the effects of JP-1302 (a selective alpha2C antagonist), BRL-44408 (a selective alpha2A antagonist) and yohimbine (a non-selective alpha2 antagonist) on haloperidol-induced bradykinesia and catalepsy in mice to elucidate the role of alpha2 adrenoceptor subtypes in modifying extrapyramidal motor
    Shawquia Young et al.
    Basic & clinical pharmacology & toxicology, 107(2), 690-697 (2010-04-01)
    Previously, we reported that antinociceptive synergism of a 5-HT(3)/alpha(2)-adrenoceptor ligand MD-354 (m-chlorophenylguanidine) and clonidine combination occurs, in part, through a 5-HT(3) receptor antagonist mechanism. In the present investigation, a possible role for alpha(2)-adrenoceptors was examined. Mechanistic studies using yohimbine (a
    Roberto T Sudo et al.
    The journal of pain : official journal of the American Pain Society, 11(1), 71-78 (2009-10-27)
    Finding new chemicals or adjuvants with analgesic effects in the central nervous system is clinically relevant due to the limited number of drugs with these properties. Here, we present PT-31, which is chemically related to 3-benzyl-imidazolidine, with an analgesic profile
    View All Related Papers

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