C0400

Carmustine

≥98% (TLC), oily liquid to amorphous solid, DNA alkylating agent

• Synonym(s): 1,3-Bis(2-chloroethyl)-1-nitrosourea, BCNU
• Empirical Formula (Hill Notation): C₅H₉Cl₂N₃O₂
• CAS Number: 154-93-8
• Molecular Weight: 214.05
• EC Number: 205-838-2
• MDL number: MFCD00057706
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278289
• NACRES: NA.77

Properties

• Product Name: Carmustine, ≥98%
• Quality Level: 200
• assay: ≥98%
• form: (Oily liquid to amorphous solid)
• mp: 30 °C (lit.)
• solubility: ethanol: 19.60-20.40 mg/mL, clear, pale yellow to yellow
• originator: Bristol-Myers Squibb
• storage temp.: −20°C
• SMILES string: ClCCNC(=O)N(CCCl)N=O
• InChI: 1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
• InChI key: DLGOEMSEDOSKAD-UHFFFAOYSA-N
• Gene Information: human ... GSR(2936)

Description

General description

Carmustine is a mustard gas related β-chloro-nitrosourea compound, which is used in chemotherapy. It inhibits DNA replication and DNA transcription.

Application

Carmustine has been used to select transduced cells expressing MGMTP140K, a foamy virus vector. It has also been used in fluorescence-activated cell sorting (FACS) assay, to test the response of cell lines to carmustine.

Biochem/physiol Actions

Carmustine is a DNA alkylating agent causing DNA interstrand crosslinks. Effective against glioma and other solid tumors.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300,H350,H360
• pcodes: P201 - P301 + P310 + P330
• Hazard Classifications: Acute Tox. 2 Oral - Carc. 1B - Repr. 1B
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges