Name: HER2 (676-end), active, GST tagged human
Brand: SIGMA
Price: 678 CAD

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recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

200

product line

PRECISIO^® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

9-13 nmol/min·mg

mol wt

~116 kDa

UniProt accession no.

P04626

relevant disease(s)

cancer (breast)

shipped in

dry ice

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This Item	SRP5325	SRP5020	F7930
H3040 HER2 (676-end), active, GST tagged human	SRP5325 EGFR (L861Q), active, GST tagged human	SRP5020 DDR1 (444-end), active, GST tagged human	F7930 FGFR3 (397-end), active, GST tagged human
assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)	assay ≥70% (SDS-PAGE)
recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells	recombinant expressed in baculovirus infected Sf9 cells
mol wt ~116 kDa	mol wt ~89 kDa	mol wt ~77 kDa	mol wt ~73 kDa
form buffered aqueous glycerol solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution
UniProt accession no. P04626	UniProt accession no. -	UniProt accession no. -	UniProt accession no. P22607
Gene Information human ... ERBB2(2064)	Gene Information human ... EGFR(1956)	Gene Information human ... DDR1(780)	Gene Information human ... FGFR3(2261)

General description

HER2 (eceptor tyrosine-protein kinase erbB-2) is a cell surface-associated glycoprotein tyrosine kinase receptor.[1][2]

Biochem/physiol Actions

HER2 (receptor tyrosine-protein kinase erbB-2) is an oncogene and is up-regulated in breast cancer. Overexpression of HER2 is associated with uncontrolled cellular proliferation, resistance to apoptotic cell death and increased motility.[1][2]

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Specification Sheet

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The ErbB2 signaling network as a target for breast cancer therapy.

Ali Badache et al.

Journal of mammary gland biology and neoplasia, 11(1), 13-25 (2006-09-02)

Overexpression of the ErbB2/Her2 receptor tyrosine kinase in breast cancers is associated with the most aggressive tumors. Experimental studies have revealed that ErbB2 shows many features of a therapeutic target: ErbB2 is able to confer many of the characteristics of

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.

R M Hudziak et al.

Proceedings of the National Academy of Sciences of the United States of America, 84(20), 7159-7163 (1987-10-01)

The HER2 gene encodes a cell-surface glycoprotein with extensive homology to the epidermal growth factor receptor. Recently it was found to be amplified in about 30% of primary human breast malignancies. In experiments designed to assess the role of the

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HER2 (676-end), active, GST tagged human

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

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