I3282
Monoclonal Anti-Interleukin-10 Receptor α antibody produced in mouse
clone 37607, purified immunoglobulin, lyophilized powder
Synonym(s):
Anti-IL-10 Receptor α
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About This Item
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
37607, monoclonal
form
lyophilized powder
species reactivity
human
technique(s)
neutralization: suitable
isotype
IgG1
General description
Interleukin-10 (IL-10) is a pleotropic cytokine with anti-inflammatory and immunosuppressive functions. It is the key cytokine that regulates the host inflammatory responses to bacterial, fungal and viral pathogens. IL-10 is secreted by a variety of cells including T cells, B cells, dendritic cells, eosinophils, natural killer cells and mast cells. The effects of IL-10 are mediated by binding to the IL-10R, consisting of α and β subunits. The signalling through IL-10R activates Jak1, Tyk2 protein kinases and JAK/STAT3 pathways. IL-10R is involved in suppression of innate immunity to kill pathogens and inhibits the release of reactive oxygen and nitrogen species from activated macrophages. Regulation of IL-10R mediated signalling is important in infections, inflammatory responses in autoimmune encephalomyelitis, endotoxic shock and chronic enterocolitis
Monoclonal Anti-Interleukin-10 Receptor α (IL-10 Rα) recognizes human IL-10 Rα. The antibody does not cross-react with recombinant mouse IL-10 Ra.
Monoclonal Anti-Interleukin-10 Receptor α (IL-10 Rα) recognizes human IL-10 Rα. The antibody does not cross-react with recombinant mouse IL-10 Ra.
Specificity
The antibody has the ability to block cell surface human IL-10 Rα mediated bioactivity induced by recombinant human IL-10. The antibody does not cross-react with mouse IL-10 Rα.
Immunogen
purified recombinant human IL-10 soluble receptor α expressed in insect Sf 21 cells.
Application
Anti-interleukin-10 receptor α antibody is suitable for neutralization reactions (ND50 is 0.03-0.1 μg/ml).
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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