I8909

Anti-Interleukin-1α antibody produced in goat

IgG fraction of antiserum, lyophilized powder

• Synonym(s): Anti-IL-1α
• MDL number: MFCD00165461
• UNSPSC Code: 51111800
• NACRES: NA.41

Properties

• biological source: goat
• Quality Level: 100
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• species reactivity: human
• technique(s): neutralization: suitable; western blot: 1-2 μg/mL
• UniProt accession no.: P01583

Description

General description

Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced by the activation of NF-κ B transcription factor in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signalling through IL-1 receptor type 1. A variety of cells such as macrophages, epithelial cells, fibroblasts, keratinocytes, monocytes and dendritic cells secrete IL-1α. Both IL-1α and IL-1β are important in acquired immunity, inflammation, response to infection and production of matrix metalloproteinases (MMPs). The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation. Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis
Anti-interleukin-1α specifically reacts with human IL-1α. It does not react with human IL-1β and mouse IL-1β or mouse IL-1α in neutralization reactions. It shows 5% cross reactivity with mouse IL-1α in immunoblotting applications.

Immunogen

purified, E. coli-derived recombinant human interleukin-1α.

Application

Anti-interleukin 1α antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. It is also suitable for neutralization reactions.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Safety Information

• Storage Class: 10 - Combustible liquids