Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

I9660

Sigma-Aldrich

Anti-Integrin α2b (CD41) antibody, Mouse monoclonal

clone PM6/248, purified from hybridoma cell culture

Synonym(s):

Anti-CD41, Anti-CD41B, Anti-GP2B, Anti-GTA, Anti-ITGA2B integrin, alpha 2b

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

MDL number:
MFCD00211671
UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

PM6/248, monoclonal

form

buffered aqueous solution

species reactivity

baboon, human

concentration

~1.0 mg/mL

technique(s)

flow cytometry: 1-2 μg/mL using human platelets
immunoprecipitation (IP): suitable

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
1.038701.079931.05443
GranuCult® Brain Heart Infusion broth ISO 6888, To support the growth of fastidious and non-fastidious microorganisms

1.10493

GranuCult® Brain Heart Infusion broth

GranuCult® prime Brain Heart Infusion Agar acc. FDA-BAM

1.03870

GranuCult® prime Brain Heart Infusion Agar

GranuCult® BAT Broth according to IFU Method No. 12, For the enrichment of Alicyclobacillus spp.

1.07993

GranuCult® BAT Broth

GranuCult® Nutrient Broth acc. FDA-BAM, for general cultivation of less fastidious microorganisms

1.05443

GranuCult® Nutrient Broth

agency

APHA, ISO 6888

agency

-

agency

according to IFU Method No. 12

agency

FDA-BAM

application(s)

food and beverages
microbiology
pathogen testing

application(s)

food and beverages
pharmaceutical

application(s)

bioburden testing
food and beverages

application(s)

food and beverages
pharmaceutical

form

granular

form

powder

form

medium granules (dehydrated culture medium (DCM))

form

granular

technique(s)

microbiological culture: suitable

technique(s)

microbe id | specific enzyme detection: suitable, microbiological culture: suitable

technique(s)

-

technique(s)

microbiological culture: suitable

manufacturer/tradename

GranuCult® prime

manufacturer/tradename

-

manufacturer/tradename

GranuCult® prime

manufacturer/tradename

GranuCult® prime

suitability

heterotrophic bacteria

suitability

Enterococcus spp., Haemophilus spp., Pneumococcus spp., Staphylococcus spp., Streptococcus spp.

suitability

Alicyclobacillus spp. (spp)

suitability

heterotrophic bacteria

General description

The gene ITGA2B (integrin subunit α 2b) encodes one of the 18 α subunits of integrins, which are transmembrane α/β heterodimers. The heterodimers, in mammals, are made up of a combination of one of 18 possible α subunits together with one of eight β subunits. The α and β subunits are type-I membrane proteins that contain a single transmembrane region linking a large extracellular domain and short noncatalytic cytoplasmic tail.

Immunogen

human platelet membranes

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Biochem/physiol Actions

Integrins function in various cellular processes, such as tissue migration during embryogenesis, cellular adhesion, cancer metastases, and lymphocyte helper and killer cell functions. The heterodimer αIIbβ3 functions primarily in platelet aggregation, a crucial process in hemostasis and thrombosis. Integrin αIIbβ3, also referred to as glycoprotein IIbIIIa is a major adhesion receptor on platelets that is capable of binding to fibrinogen upon platelet stimulation. Defects in this gene have been associated with Glanzmann thrombasthenia, an autosomal recessive bleeding disorder.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    075M4833V
    029K4760

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Search for a COA

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Catherine Huang et al.
    Breast cancer research : BCR, 13(4), R84-R84 (2011-09-03)
    The overexpression of human epidermal growth factor receptor (HER)-2 in 20% of human breast cancers and its association with aggressive growth has led to widespread use of HER2-targeted therapies, such as trastuzumab (T) and lapatinib (L). Despite the success of
    Jaewon Han et al.
    Current biology : CB, 16(18), 1796-1806 (2006-09-19)
    Integrin receptors, composed of transmembrane alpha and beta subunits, are essential for the development and functioning of multicellular animals. Agonist stimulation leads cells to regulate integrin affinity ("activation"), thus controlling cell adhesion and migration, controlling extracellular-matrix assembly, and contributing to
    Y-Q Ma et al.
    Journal of thrombosis and haemostasis : JTH, 5(7), 1345-1352 (2007-07-20)
    Integrin alpha(IIb)beta(3) plays a critical role in platelet aggregation, a central response in hemostasis and thrombosis. This function of alpha(IIb)beta(3) depends upon a transition from a resting to an activated state such that it acquires the capacity to bind soluble
    Melanie A Burkhardt et al.
    Scientific reports, 6, 21071-21071 (2016-02-18)
    Low correlations of cell culture data with clinical outcomes pose major medical challenges with costly consequences. While the majority of biomaterials are tested using in vitro cell monocultures, the importance of synergistic interactions between different cell types on paracrine signalling
    Vincent Milleret et al.
    European cells & materials, 21, 430-444 (2011-05-24)
    Titanium implants are most commonly used for bone augmentation and replacement due to their favorable osseointegration properties. Here, hyperhydrophilic sand-blasted and acid-etched (SBA) titanium surfaces were produced by alkali treatment and their responses to partially heparinized whole human blood were
    View All Related Papers

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service