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K1632

Sigma-Aldrich

Kininogen high molecular weight, Two Chain from human plasma

lyophilized powder

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About This Item

MDL number:
UNSPSC Code:
12352202
NACRES:
NA.61
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biological source

human plasma

Quality Level

form

lyophilized powder

solubility

H2O: soluble 0.1 mg protein/mL

UniProt accession no.

storage temp.

−20°C

Gene Information

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This Item
H9291F4883B1901
biological source

human plasma

biological source

human plasma

biological source

human plasma

biological source

-

form

lyophilized powder

form

lyophilized powder

form

powder

form

powder

solubility

H2O: soluble 0.1 mg protein/mL

solubility

-

solubility

0.9% NaCl: soluble

solubility

-

Gene Information

human ... KNG1(3827), KNG1 (includes EG:3827)(3827)

Gene Information

human ... HPX(3263)

Gene Information

human ... FGA(2243), FGB(2244), FGG(2266)

Gene Information

human ... KNG1 (includes EG:3827)(3827)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

UniProt accession no.

P01042

UniProt accession no.

-

UniProt accession no.

P02671, P02675, P02679

UniProt accession no.

P01042

General description

HK (KNG1) gene is mapped to human chromosome 3q27.3. It is a glycoprotein.[1]
High-molecular-weight kininogen (HK) is the substrate and cofactor of the plasma kallikrein-kinin system (KKS). It is present at a concentration of 660 nM on the plasma and binds to platelet GPI-V-IX complex.

Biochem/physiol Actions

High molecular weight kininogen, two chain, is a participant in contact phase activation of the intrinsic blood coagulation cascade that forms a substrate on which blood factor XI is held in proximity to factor XII allowing reciprocal activation of the two factors. It is also involved in the activation of prekallikrein. High molecular weight kininogen binds to proteoglycans on the surface of platelets, endothelial cells, and other cell types. Domain 5 of high molecular weight kininogen inhibits platelet aggregation and angiogenesis.
High-molecular-weight kininogen (HK) inhibits binding of thrombin to platelets.[2]

Packaging

Package size based on protein content

Physical form

Lyophilized from 4 mM sodium acetate, pH 5.3, 0.15 M NaCl

Preparation Note

Prepared by kallikrein digestion of human kininogen. Purified to remove kallikrein and kinin.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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