N1628

Novobiocin sodium salt

≥90% (HPLC)

• Synonym(s): Albamycin, Albamycin Sodium, Cathomycin sodium
• Empirical Formula (Hill Notation): C₃₁H₃₅N₂NaO₁₁
• CAS Number: 1476-53-5
• Molecular Weight: 634.61
• Beilstein/REAXYS Number: 3892910
• EC Number: 216-023-6
• UNSPSC Code: 51286504
• PubChem Substance ID: 24897508
• NACRES: NA.85

Properties

• biological source: (STREPTOMYCES NIVEUS)
• Quality Level: 200
• assay: ≥90% (HPLC)
• form: powder
• storage condition: (Tightly closed. Dry. )
• color: white to yellow
• antibiotic activity spectrum: Gram-positive bacteria
• mode of action: DNA synthesis | interferes; enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: [Na+].CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3C([O-])=C(NC(=O)c4ccc(O)c(C\C=C(\C)C)c4)C(=O)Oc3c2C)OC1(C)C

Description

General description

Novobiocin sodium salt is an antibiotic derived from soil bacteria. Novobiocin inhibits the action of bacterial DNA gyrase and belongs to a class of compounds called coumarin antibiotics. Coumarins are heterocyclic compounds with a wide range of biological activity, including antibacterial, anticoagulant, antioxidant, anti-inflammatory, antiviral, antitumor, and enzyme inhibitory effects.

Application

For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.

Novobiocin Sodium Salt, an inhibitor of Hsp90, can be used:

• in the research heat shock protein inhibition and to produce positively supercoiled plasmid DNA
• in the research on the efficacy of probiotics
• in the research on the efficacy of human monocytes and dendritic cells for T-cell replication

Biochem/physiol Actions

Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.
Antimicrobial spectrum: Gram-positive bacterial.

Novobiocin inhibits DNA synthesis by inhibiting the GyrB subunit of the Topoisomerase enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB.

Features and Benefits

High quality antibiotic suitable for mulitple research applications

Storage and Stability

Stored in frozen aliquots, Keep container tightly closed in a dry and well-ventilated place. Light sensitive

Other Notes

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Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H317,H319
• pcodes: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves