P4354

Monoclonal Anti-p19^INK4d antibody produced in mouse

clone DCS-100, ascites fluid

• Synonym(s): Anti-INK4D, Anti-p19, Anti-p19-INK4D
• MDL number: MFCD01324442
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 200
• conjugate: unconjugated
• antibody form: ascites fluid
• antibody product type: primary antibodies
• clone: DCS-100, monoclonal
• mol wt: antigen 19 kDa
• contains: 15 mM sodium azide
• species reactivity: human
• technique(s): immunocytochemistry: suitable; immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; immunoprecipitation (IP): suitable; microarray: suitable; western blot: 1:1,000 using a cultured human tumor cell line extract
• isotype: IgG1
• UniProt accession no.: P55273
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CDKN2D(1032)

Description

General description

Cyclin dependent kinase inhibitor 2D (CDKN2D), also referred to as p19INK4d, is part of the inhibitors of cyclin-dependent kinases (INK4) family. It consists of 166 amino acids and five ankyrin-like repeats that aid in protein-protein interactions. The gene encoding this protein is localized on human chromosome 19p13.

Specificity

Shows no cross-reactivity with other closely related Cdk inhibitors, such as p15^INK4b, p16^INK4a and p18^INK4c.

Immunogen

recombinant human p19^INK4d.

Application

Monoclonal Anti-p19INK4d antibody produced in mouse has been used in microarray.

Biochem/physiol Actions

Cyclin dependent kinase inhibitor 2D (CDKN2D) functions as a modulator of the cell cycle and has a role in DNA damage response. It acts as a chromatin accessibility factor. The protein associates with cyclin-dependent kinase 4 and 6 and inhibits their kinase activity.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable