recombinant
expressed in baculovirus infected Sf9 cells
Quality Level
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
159-215 nmol/min·mg
mol wt
~108 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... RPS6KA1(6195)
General description
Ribosomal protein S6 kinase α-1 (RPS6KA1) or RSK1 is a member of the RSK (ribosomal S6 kinase) family that consists of growth factor-regulated serine/threonine kinases. RSK1 contains 2 nonidentical kinase catalytic domains. RSK1 encodes a predicted 735-amino acid protein containing 2 distinct consensus ATP-binding site sequences. RSK1 transcript is present in lymphocytes, skeletal muscle, liver, and adipose tissue.
Biochem/physiol Actions
Ribosomal S6 kinases (RSKs) are implicated in the activation of the mitogen-activated kinase (MAPK) cascade and the stimulation of cell proliferation and differentiation. The protein suppresses the pro-apoptotic function of BAD by phosphorylating it. RSK1 phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signaling pathway.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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