R109

Ro 15-4513

solid

• Synonym(s): Ethyl 8-azido-6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate, Ro15-4513
• Empirical Formula (Hill Notation): C₁₅H₁₄N₆O₃
• CAS Number: 91917-65-6
• Molecular Weight: 326.31
• MDL number: MFCD00078598
• UNSPSC Code: 12352200
• PubChem Substance ID: 24899343
• NACRES: NA.77

Properties

• form: solid
• Quality Level: 100
• color: tan
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL; H₂O: insoluble; methanol: soluble
• originator: Roche
• SMILES string: CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(ccc-23)N=[N+]=[N-]
• InChI: 1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3
• InChI key: CFSOJZTUTOQNIA-UHFFFAOYSA-N
• Gene Information: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA5(2558), GABRA6(2559) ; rat ... Gabrg1(140674)

Description

Application

Ro 15-4513 has been used as a benzodiazepine (Bz) inverse agonist in rats and to test its binding with diazepam-sensitive (DS) receptors in in vitro radioligand binding studies.

Biochem/physiol Actions

Ro 15-4513 is benzodiazepine receptor partial inverse agonist. It elicits anxiogenic property and is an ethanol antagonist. It elicits a high affinity towards diazepam sensitive and insensitive sites in the cerebellar region. Ro 15-4513 possesses an imidazo ring and is an imidazobenzodiazepine.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)