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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32
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species reactivity

mouse

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type serum sample(s)
sample type cell culture supernatant(s)
sample type plasma

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.8 ng/ml

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Grem1(23892)

Related Categories

General description

Gremlin-1 (GREM1) is part of the secreted, cysteine knot DAN family of bone morphogenetic protein antagonists. It has a molecular weight of 24–26kDa.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Biochem/physiol Actions

Gremlin-1 (GREM1) has a role in embryogenesis. It also has a role in cell functions during development. GREM1 acts as an antagonist of bone morphogenetic proteins (BMP). The protein influences chondrogenesis, outgrowth and apoptosis in limb bud development and has a role in kidney formation. It inhibits the activity of BMP2 and BMP4. GREM1 is involved in angiogenesis, bone formation, bone mass and pulmonary hypertension. Knockout of this gene in mice leads to developmental abnormalities.

Other Notes

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

pictograms

Corrosion
GHS05

signalword

Warning

hcodes

H290

Hazard Classifications

Met. Corr. 1

Storage Class

8A - Combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SAMPLE
0212F0567

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