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SAB1401203

Sigma-Aldrich

Anti-IFNAR2 antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

Synonym(s):

IFN-R, IFN-alpha-REC, IFNABR, IFNARB

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

BC002793

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Chromolith® WP 300 Epoxy L × I.D. 25 mm x 4.6 mm HPLC column

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Chromolith® WP 300 Epoxy L × I.D. 50 mm x 4.6 mm HPLC column

1.52251

Chromolith® WP 300 Epoxy

product line

Chromolith®

product line

Chromolith®

product line

Chromolith®

product line

Chromolith®

matrix

monolithic silica

matrix

monolithic silica

matrix

monolithic silica

matrix

monolithic silica

pore size

2 μm macroporosity, 30 nm mesoporosity

pore size

2 μm macroporosity, 30 nm mesoporosity

pore size

2 μm macroporosity, 30 nm mesoporosity

pore size

2 μm macroporosity, 30 nm mesoporosity

technique(s)

HPLC: suitable, LC/MS: suitable

technique(s)

HPLC: suitable, LC/MS: suitable

technique(s)

HPLC: suitable, LC/MS: suitable

technique(s)

HPLC: suitable, LC/MS: suitable

material

PEEK column

material

PEEK column

material

PEEK column

material

PEEK column

General description

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. (provided by RefSeq)

Immunogen

IFNAR2 (AAH02793.1, 1 a.a. ~ 331 a.a) full-length human protein.

Sequence
MLLSQNAFIVRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAESAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLRQGLTKGWNAVAIHRCSHNALQSETPELKQSSCLSFPSSWDYKRASLCPSD

Biochem/physiol Actions

The IFN (interferon) response is a part of the first line defense system against infection, which requires the binding of IFNs to the receptors (IFNAR1 and IFNAR2) for its activation. IFNAR2 (interferon αand βreceptor subunit 2) is associated with the JAK-STAT (Janus - signal transducer and activator of transcription) signaling pathway.

Physical form

Solution in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    DC171
    09175

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    C Aucan et al.
    Genes and immunity, 4(4), 275-282 (2003-05-23)
    The chromosome 21q22.11 cytokine receptor cluster contains four genes that encode subunits of the receptors for the cytokines interleukin-10 and interferon-alpha, -beta and -gamma that may have a role in malaria pathogenesis. A total of 15 polymorphic markers located within
    Nanaocha Sharma et al.
    The Journal of biological chemistry, 291(7), 3371-3384 (2015-12-19)
    Type I interferons serve as the first line of defense against pathogen invasion. Binding of IFNs to its receptors, IFNAR1 and IFNAR2, is leading to activation of the IFN response. To determine whether structural perturbations observed during binding are propagated
    Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia.
    Aucan C
    Genes and Immunity, 4(4), 275-282 (2003)
    Type I Interferon Signaling Is Decoupled from Specific Receptor Orientation through Lenient Requirements of the Transmembrane Domain.
    Sharma N
    The Journal of Biological Chemistry, 291(7), 3371-3384 (2016)
    Impaired expression of type I and type II interferon receptors in HCV-associated chronic liver disease and liver cirrhosis.
    Chandra PK
    PLoS ONE, 9(9), 1-10 (2014)
    View All Related Papers

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