SAB4502259
Anti-OCT3 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
OCT3, OCT4, OCTAMER-BINDING TRANSCRIPTION FACTOR 3, OTF3, OTF4
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About This Item
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 38 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
application(s)
research pathology
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... POU5F1(5460)
General description
Anti-OCT3 Antibody detects endogenous levels of total OCT3 protein.
Octamer-binding transcription factor 3 (OCT3)/OCT4 is encoded by the gene spanning 1420 bases of genomic DNA mapped to human chromosome 6p21.33. OCT3/OCT4 is a transcription factor that belongs to the transcription Pit-Oct-Unc (POU)family. This protein contains a POU-specific homeodomain and DNA-binding domain. Anti-OCT3 antibody detects endogenous levels of total OCT3 protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human OCT3.
Immunogen Range: 191-240
Immunogen Range: 191-240
Application
Anti-OCT3 antibody produced in rabbit may be used in immunohistochemistry at 1:100 dilution and immunoblot at 1:1000 dilution.
Biochem/physiol Actions
Octamer-binding transcription factor 3 (OCT3)/OCT4 plays a vital role in the self-renewal and pluripotency of embryonic stem cells. It is involved in the regulation of embryonic development and cell fate determination. Overexpression of OCT4 gene aids in the progression of various types of human cancers by increasing tumorigenicity and enhancing resistance to chemotherapeutics. OCT4 expression acts as a potential cancer diagnosis and prognosis biomarker. Reduced expression of the OCT4 gene suppresses the growth of pancreatic cancer cells by blocking the AKT pathway. Therefore, OCT4 protein may be used as an effective therapeutic target for pancreatic cancer treatment.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Manal S Fawzy et al.
Oxidative medicine and cellular longevity, 2018, 8753063-8753063 (2018-06-01)
Glioblastoma multiforme (GBM) (grade IV astrocytoma) has been assumed to be the most fatal type of glioma with low survival and high recurrence rates, even after prompt surgical removal and aggressive courses of treatment. Transcriptional reprogramming to stem cell-like state
Ozlem Yildirim et al.
PLoS genetics, 10(8), e1004515-e1004515 (2014-08-08)
Dynamic exchange of a subset of nucleosomes in vivo plays important roles in epigenetic inheritance of chromatin states, chromatin insulator function, chromosome folding, and the maintenance of the pluripotent state of embryonic stem cells. Here, we extend a pulse-chase strategy
Riccardo Di Fiore et al.
International journal of oncology, 45(5), 2013-2023 (2014-09-02)
Osteosarcoma (OS) is the most common type of bone cancer, with a peak incidence in the early childhood. Emerging evidence suggests that treatments targeting cancer stem cells (CSCs) within a tumor can halt cancer and improve patient survival. MicroRNAs (miRNAs)
Soichiro Honjo et al.
International journal of oncology, 45(2), 567-574 (2014-05-27)
Our clinical study indicates esophageal adenocarcinoma patients on metformin had a better treatment response than those without metformin. However, the effects of metformin and the mechanisms of its action in esophageal cancer (EC) are unclear. EC cell lines were used
Min Wang et al.
International journal of oncology, 45(1), 362-372 (2014-05-09)
Evidence in literature has demonstrated that some microRNAs (miRNAs) play a pivotal role in most solid tumor metastasis. Previous studies have showed that miR-100 is downregulated in human prostate cancer tissue compared to normal prostate and also significantly decreased in
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