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SAB4502562

Sigma-Aldrich

Anti-RAD21 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Double-strand-break repair protein rad21 homolog, Hhr21, NXP-1, Nuclear matrix protein 1, SCC1 homolog

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
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biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 71 kDa

species reactivity

mouse, human

concentration

~1 mg/mL

General description

Anti-RAD21 Antibody detects endogenous levels of total RAD21 protein.
RAD21 (RAD21 homolog, S. pombe) is a novel nuclear protein located on chromosome 8q24.

Immunogen

The antiserum was produced against synthesized peptide derived from human RAD21.

Immunogen Range: 521-570

Application

Anti-RAD21, C-Terminal antibody produced in rabbit is suitable for indirect ELISA and western blot applications.

Biochem/physiol Actions

RAD21 (RAD21 homolog, S. pombe) plays a crucial role in normal cell division. It acts as a main component of the cohesin complex for the proper chromosomal arrangement during cell division. The protein possesses two mitotic cleavage sites for the attachment of separase. It has been shown experimentally that at the beginning of anaphase stage, a caspase-like Esp1/separase attaches to the cleavage site of RAD21 and initiate sister chromatid separation, which is an essential step for the completion of cytokinesis. During double strand DNA damage repair, it helps the two DNA strands to adhere with each other. Mutation in RAD21 causes a congenital phenotype, cohesinopathy in humans characterized with growth retardation and minor skeletal anomalies.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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