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SMB01050

Sigma-Aldrich

Licochalcone B

≥85% (LC/MS-ELSD)

Synonym(s):

(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one, 3,4,4′-trihydroxy-2-methoxychalcone

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10 MG
883,00 $

883,00 $


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10 MG
883,00 $

About This Item

Empirical Formula (Hill Notation):
C16H14O5
CAS Number:
Molecular Weight:
286.28
MDL number:
UNSPSC Code:
12352205
NACRES:
NA.25

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biological source

plant

assay

≥85% (LC/MS-ELSD)

form

solid

mol wt

286.28

solubility

water: slightly soluble

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

SMILES string

O(C)c1c(c(ccc1\C=C\C(=O)c2ccc(cc2)O)O)O

InChI

1S/C16H14O5/c1-21-16-11(5-9-14(19)15(16)20)4-8-13(18)10-2-6-12(17)7-3-10/h2-9,17,19-20H,1H3/b8-4+

InChI key

DRDRYGIIYOPBBZ-XBXARRHUSA-N

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feature

DNase free, Pure packed, RNase free

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feature

DNase free, RNase free, racked

manufacturer/tradename

Molecular BioProducts 3771

manufacturer/tradename

Molecular BioProducts 3571

manufacturer/tradename

Molecular BioProducts 3552

manufacturer/tradename

Molecular BioProducts 3582

sterility

non-sterile

sterility

sterile

sterility

non-sterile

sterility

non-sterile

packaging

pack of 960 ea

packaging

pack of 960 ea

packaging

pack of 960 ea

packaging

pack of 800 ea

maximum volume

300 μL

maximum volume

300 μL

maximum volume

200 μL

maximum volume

1000 μL

size

1-300 μL

size

1-300 μL

size

0.5-200 μL

size

-

General description

Licochalcone B is a prenylated flavonoid classified within the group of retrochalcones. This bioactive natural compound is commonly sourced from Glycyrrhiza species (G. glabra, G. uralensis, G. inflata, and G. aspera) plants. Existing research indicates that this plant-derived metabolite possesses a wide array of biological activities, including antibacterial, cardioprotective, anticancer, antioxidant, antiapoptotic, neuroprotective and anti-inflammatory properties.

Application

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Biochem/physiol Actions

According to the existing research, Licochalcone B exerts its effects through multiple pathways, making it a versatile candidate for various therapeutic applications. It effectively combats inflammation by inhibiting NF-κB activation induced by LPS, leading to reduced production of NO, TNFα, and MCP-1. For bladder cancer, Licochalcone B demonstrates its potential by inducing S phase arrest, modulating cell cycle-related proteins, suppressing anti-apoptotic factors, and activating caspase-3. These actions collectively limit tumor growth in vivo, suggesting its utility in both bladder cancer therapy and prevention. Furthermore, Licochalcone B showcases robust antioxidant capabilities, successfully mitigating lipid peroxidation and lowering ROS production. It also exhibits anti-inflammatory properties by decreasing the release of NO, IL-6, and PGE2 in response to LPS. Furthermore, Licochalcone B emerges as a promising candidate for Alzheimer′s disease treatment, effectively preventing Aβ42 aggregation, chelating metal ions, and providing neuroprotection.

Features and Benefits

  • High quality compound suitable for multiple research applications
  • Compatible with HPLC and mass spectrometry techniques

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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